Earticle

초록

영어

The purpose of this study was to investigate whether regular treadmill exercise after traumatic brain injury (TBI) positively affects the regener-ative environment in the motor cortex and hippocampus of the brain. Subjects were randomly divided into three groups: the normal control (Norm, n=8), the TBI+sedentary group (TBI+SED, n=8), and the TBI+ treadmill exercise group (TBI+Ex, n=8). Following a 2-week post-TBI recovery period, treadmill exercise was performed regularly for 4 weeks. The results showed that regular walking exercise after TBI increased the expression of growth associated protein-43 and tropomyosin recep-tor kinase-B, which are associated with neuronal survival, in both the motor cortex and hippocampus. The TBI+SED exhibited elevated glial fibrillary acidic protein and phosphorylated mammalian target of rapa-mycin signaling in both the motor cortex and hippocampus of the brain. In contrast, phosphorylated phosphatase and tensin homolog (p-PTEN) expression showed region-specific patterns: in the motor cortex, p-PTEN levels were higher in the TBI+SED than the Norm group and further increased following treadmill exercise, whereas in the hippocampus, p-PTEN expression decreased after TBI but was significantly elevated in the TBI+Ex group. These findings indicated that regular exercise after TBI might reduce glial scar formation and promote neural regeneration by elevating PTEN expression and inhibiting the mammalian target of rapamycin signaling pathway.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Traumatic brain injury
Exercise program
Hematoxylin and eosin staining
Immunohistochemical analysis
Western blot analysis
Statistical analysis
RESULTS
Histological changes in motor cortex and hippocampus after TBI
Changes of GAP-43 and TrkB in the motor cortex and hippocampus after TBI
Changes in reactive astrocyte-related proteins in the motor cortex and hippocampus after TBI
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Woo-Hyeok Yang [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Dong-Eun Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Young-Pyo Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613