Earticle

초록

영어

Exosome-like particles (ELPs) derived from natural products have attracted considerable interest for drug delivery and therapeutic applications. Mushroom-derived exosome-like particles (MELPs) are an unexplored group with significant biomedical potential. Because medicinal and edible mushrooms are rich in bioactive compounds, such as polysaccharides, proteins, and phenolic acids, it is likely that their ELPs also carry these compounds during their biogenesis. Hence, MELPs containing these beneficial compounds, which exhibit favorable characteristics such as nanosize, stability, and cellular uptake properties, should be considered a novel potential natural nanocarrier. Here, we have detailed the current understanding of MELPs in terms of their biological functions, physicochemical characteristics, molecular cargo, and isolation methods. We have also highlighted their potential applications in cancer therapy, immune modulation, inflammation, and microbiome regulation. Moreover, we have outlined the challenges and future directions for standardizing the isolation protocol to yield large-scale production and for elucidating the mechanistic pathways. As MELP research advances, it may emerge as a next-generation nanocarrier in natural therapeutics and green nanomedicine.

목차

ABSTRACT
Introduction to Mushroom Exosomes and Exosome-Like Particles
Insights into Fungal Nanovesicle Formation
Isolation and Profiling of MELPs
Molecular Composition and Cargo
Therapeutic Applications
Challenges and Limitations
Future Perspectives
Conclusion
Acknowledgement
Author Contribution
REFERENCES

키워드

저자

• Akhil Raj [ Department of Chemical Engineering, Graduate School of Chosun University ]
• Hyun-Jae Shin [ Department of Chemical Engineering, Graduate School of Chosun University ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국버섯학회지 [Journal of MUSHROOMS]

• 간기

  계간

• pISSN

  1738-0294

• eISSN

  2288-8853

• 수록기간

  2003~2025

• 등재여부

  KCI 등재

• 십진분류

  KDC 525 DDC 635