Earticle

초록

영어

Background: This study evaluated the impact of intra-abdominal lidocaine and systemic meloxicam, alone and in combination, on oxidative stress biomarkers in healthy dogs undergoing elective ovariohysterectomy (OHE). Methods: Twenty-eight female dogs presenting to the Aydın Adnan Menderes University Veterinary Teaching Hospital were randomly assigned to one of four groups (n = 7 each): Control (OHE only), Lidocaine (1 mg/kg sprayed intraperitoneally at surgical sites), Meloxicam (0.2 mg/kg SC post-closure), and Lidocaine + Meloxicam (both treatments as above). Blood was sampled pre-operatively and at 2, 12, and 24 hours post-surgery. Serum concentrations of malondialdehyde (MDA), catalase (CAT), and glutathione peroxidase (GSH-Px) were quantified as indices of lipid peroxidation and antioxidant capacity. Results: In the combined-treatment group, MDA, CAT, and GSH-Px levels declined significantly over time, indicating attenuated oxidative stress. In contrast, lidocaine alone produced a significant time-dependent decrease only in CAT activity, while meloxicam alone did not significantly alter any marker. Conclusions: These findings suggest that the synergistic use of intraperitoneal lidocaine with systemic meloxicam more effectively mitigates postoperative oxidative stress than either agent alone, and may represent a beneficial analgesic–antiinflammatory strategy in canine OHE.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Ethical approval and consent
Animals and experimental design
Anesthetic and surgical protocol
Blood sampling and biochemical assays
Statistical analysis
RESULTS
DISCUSSION
CONCLUSION
REFERENCES

키워드

저자

• Abdullah Gündüz [ Department of Obstetrics and Gynecology, Aydın Adnan Menderes University Faculty of Veterinary Medicine, Işıklı mah Efeler-AYDIN, Aydin 09010, Türkiye ]
• Hayrettin Çetin [ Department of Obstetrics and Gynecology, Aydın Adnan Menderes University Faculty of Veterinary Medicine, Işıklı mah Efeler-AYDIN, Aydin 09010, Türkiye ]
• Sanan Raza [ Department of Clinical Sciences, Theriogenology Section, University of Veterinary and Animal Sciences, Sub-campus, Jhang 35200, Pakistan ] Corresponding Author

참고문헌

발행기관

간행물

관심저널 등록

• 간행물명

  Journal of Animal Reproduction and Biotechnology

• 간기

  계간

• pISSN

  2671-4639

• eISSN

  2671-4663

• 수록기간

  2019~2026

• 십진분류

  KDC 527 DDC 636