Obesity is associated with reduced exercise tolerance, yet the physio-logical mechanisms underlying this impairment remain unclear. This study examined whether oxygen uptake (V̇O2) kinetics reflect autonom-ic regulation during prolonged moderate-intensity exercise in normal- weight and obese males. This cross-sectional study included nine nor-mal-weight and nine obese males (aged 20–22) who performed 30 min of constant-load cycling at 70% of ventilatory threshold to assess V̇O2 kinetics and heart rate variability (HRV) responses. V̇O2 kinetics param-eters—including the time constant (τ), which reflects the rate of car-diopulmonary and muscular adjustment to exercise, and the V̇O2 drift slope—were analyzed. HRV was assessed at rest and during exercise. Changes in HRV and their correlations with V̇O2 kinetics and perceived fatigue were evaluated. The obese group had a significantly longer τ than the normal-weight group, despite similar relative intensities. During exercise, HRV indices—including overall HRV, low-frequency, very low-frequency, and the standard deviation along the line of identity (SD2) —were significantly lower in the obese group, indicating attenuated autonomic responsiveness. In the normal-weight group, the slope was strongly correlated with the changes in the root mean square of suc-cessive differences, the high-frequency power, the standard deviation perpendicular to the line of identity (SD1), and SD1/SD2 (r=-0.769 to -0.857; P<0.05), whereas these associations were absent in the obese group. These findings suggest that in normal-weight individuals, V̇O2 ki-netics are closely linked to autonomic modulation during prolonged ex-ercise, whereas this link is disrupted in obesity, potentially leading to re-duced aerobic efficiency and greater exercise intolerance.
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Abstract INTRODUCTION MATERIALS AND METHODS Participants Study design Exercise testing protocol Measurement and analysis Statistical analysis RESULTS Participant characteristics V̇O2 kinetics and fatigue responses HRV responses DISCUSSION REFERENCES
Jatuporn Phoemsapthawee [ Department of Sports Science, Faculty of Sports and Health Science, Kasetsart University, Nakhon Pathom, Thailand ]
Corresponding Author
Surasak Phoemsapthawee [ Department of Maritime Engineering, Faculty of International Maritime Studies, Kasetsart University, Chonburi, Thailand ]