This case report presents a 38-year-old female patient with locked-in syndrome (LIS) due to cerebral infarction affecting the right lateral medulla and left pons. The purpose of this study was to evaluate the effectiveness of communication rehabilitation using an eye-tracking device. The patient underwent a four-week rehabilitation program that involved using the eye-tracking device for communication training. Over this period, she showed significant improvements in her ability to communicate through eye movements, progressing from simple word selection to sentence formation. This case demonstrates the utility of eye-tracking devices in rehabilitation programs for LIS patients and reveals the potential for enhancing patient communication through such interventions. The findings suggest that eye-tracking technology could play a crucial role in restoring their ability to communicate.