Earticle

초록

영어

Grounding, the practice of direct contact with the Earth’s surface, has been explored for its potential to alleviate inflammation and neurotoxicity. Trimethyltin (TMT) is a potent neurotoxic compound known for inducing severe central nervous system damage, particularly neuronal death and neuroinflammation in the hippocampus, which is frequently used as an animal model to study neurodegenerative disorders, such as Alzheimer disease, due to its ability to induce oxidative stress, inflammatory responses, and neurodegeneration. This study investigated the effect of a grounding mat on cognitive function, neuroinflammation, and neuroprotection in a TMT-induced neurotoxicity rats. Rats were divided into five groups: no grounding mat with saline (Nor), no grounding mat with TMT (Con), electric mat for 21 days with TMT (EM), grounding mat for 7 days with TMT (A-7D), and grounding mat for 21 days with TMT (A-21D). Cognitive function was assessed via the Y-maze test, while blood levels of interleukin (IL)-1β, IL-4, prostaglandin E2 (PGE2), and hippocampal acetylcholinesterase (AChE) were measured by enzyme- linked immunosorbent assay. The Con group showed impaired memory and elevated IL-1β and PGE2 levels, alongside reduced IL-4, compared to the Nor group. The A-7D group improved memory performance, and the A-21D group showed reductions in IL-1β and P PGE2, with increased IL-4 levels. Both A-7D and A-21D groups had elevated AChE levels compared to the Con group. These findings suggest that grounding may enhance cognitive function by reducing inflammation and promoting neuroprotection in a neurotoxicity model.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Materials
Experimental animals
Assessment of spatial cognition in the TMT-induced neurotoxicity model
Exposure to the grounding mattress
Measurement of cytokine expression in serum
Measurement of AChE activity in brain tissue
Statistical analysis
RESULTS
Cognitive effects of grounding mat exposure in a TMT-induced neurotoxicity model evaluated via Y-maze test
Effects of grounding mat exposure on cytokine expression in a TMT-induced neurotoxicity model
Effects of grounding mat exposure on hippocampal AChE activity in a TMT-induced neurotoxicity model
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Minsook Ye [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sung Ja Rhie [ Department of Beauty Design, Halla University, Wonju, Korea ]
• Woojin Jeong [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hyo-jeong Yu [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Youngsuk Kim [ DF World Corporation, Seoul, Korea ]
• Jiyoun Kim [ World Home Doctor Corporation, Anyang, Korea ]
• Jiyoun Kim [ World Home Doctor Corporation, Anyang, Korea ]
• Insop Shim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613