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In Vitro Genotoxicity Test of m-Phenylenediamine Using the Chromosomal Aberration Assay in Cultured Mammalian Cells

첫 페이지 보기
  • 발행기관
    국제인공지능학회(구 한국인터넷방송통신학회) 바로가기
  • 간행물
    The International Journal of Advanced Smart Convergence 바로가기
  • 통권
    Volume 13 Number 4 (2024.12)바로가기
  • 페이지
    pp.543-549
  • 저자
    Soo-jin Yoo, Yong-hyun Chung, Yong-taek Kwon, Jin-kwon Kim, Yeon-su Baek, Su-ho Lee, Myeong-ju Shin, Jung-hun Lee, Ji-yoen Woo, Dong-hyun Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A462061

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원문정보

초록

영어
On February 21, 2023, the Ministry of Food and Drug Safety in Korea designated five hair dye ingredients, including m-phenylenediamine, as prohibited substances in cosmetics due to potential genotoxicity, which may cause genetic damage or mutations in humans. Based on the revised regulations, products containing these ingredients have been banned from manufacture and import as of August 22, 2023. However, products manufactured or imported before this date may still be sold until August 21, 2025. Therefore, mphenylenediamine, which has already been verified to exhibit genotoxicity, was selected as the test substance for this study. The chromosomal aberration test was conducted in compliance with OECD TG 473. Mammalian cell lines, specifically the Chinese Hamster Lung (CHL/IU) cell line, were used. The test examined the chromosomal aberration-inducing potential of the test substance with and without metabolic activation. Genotoxicity assessment is not conducted based on a single test; instead, it requires a 3-battery approach, comprising from three different tests. Preliminary studies have shown a positive response in the reverse mutation assay for m-phenylenediamine. This study adds the chromosomal aberration test to compare the results, supporting the validity of a 3-battery approach and suggesting the ethical viability of cell-based toxicity testing to assess chemical hazards.

목차

Abstract
1. Introduction
2. Experiments
3. Results and Discussion
4. Conclusion
Acknowledgement
References

키워드

m-Phenylenediamine Genotoxicity Chromosomal Aberration Assay In Vitro Toxicology Mammalian Cell Culture

저자

  • Soo-jin Yoo [ M.A. Program, Dept. of Safety & Environmental Technology Convergence, Hoseo University, Korea ]
  • Yong-hyun Chung [ Dr., H&H Bio, Korea ]
  • Yong-taek Kwon [ B.A., H&H Bio, Korea ]
  • Jin-kwon Kim [ Dr., H&H Bio, Korea ]
  • Yeon-su Baek [ M.A. Program, H&H Bio, Korea ]
  • Su-ho Lee [ M.A., H&H Bio, Korea ]
  • Myeong-ju Shin [ B.A., H&H Bio, Korea ]
  • Jung-hun Lee [ M.A. Program, Dept. of Safety & Environmental Technology Convergence, Hoseo University, Korea ]
  • Ji-yoen Woo [ M.A. Program, Dept. of Safety & Environmental Technology Convergence, Hoseo University, Korea ]
  • Dong-hyun Kim [ Professor, Dept. of Safety & Environmental Technology Convergence, Hoseo University, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    국제인공지능학회(구 한국인터넷방송통신학회) [The International Association for Artificial Intelligence]
  • 설립연도
    2000
  • 분야
    공학>전자/정보통신공학
  • 소개
    인터넷방송, 인터넷 TV , 방송 통신 네트워크 및 관련 분야에 대한 국내는 물론 국제적인 학술, 기술의 진흥발전에 공헌하고 지식 정보화 사회에 기여하고자 한다.

간행물

  • 간행물명
    The International Journal of Advanced Smart Convergence
  • 간기
    계간
  • pISSN
    2288-2847
  • eISSN
    2288-2855
  • 수록기간
    2012~2025
  • 십진분류
    KDC 326 DDC 380

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