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The Anti-diabetic Effects of Fermented Banaba Leaf Complex Extracts

첫 페이지 보기
  • 발행기관
    국제인공지능학회(구 한국인터넷방송통신학회) 바로가기
  • 간행물
    The International Journal of Advanced Smart Convergence 바로가기
  • 통권
    Volume 13 Number 4 (2024.12)바로가기
  • 페이지
    pp.514-522
  • 저자
    Hyun-Kyoung Kim, Kyung-Won Ko
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A462058

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원문정보

초록

영어
As a consequence of increased obesity prevalence, diabetes mellitus (DM) has become one of the most common diseases in humans. In a preliminary study, we are found that extracts from banaba leaf complex extracts fermented with Phellinus linteus (BLPL) had the most potent effects against diabetes as compared to other fermented or crude extracts. In the present investigation, the effects of BLPL on mice and rats with streptozotocin (STZ)-induced diabetes was evaluated. Type 1 DM was induced by intra-peritoneal injection of STZ that has direct toxic effect on pancreatic β cells in mice and rats. Seven days after injection, blood glucose level of the diabetic mice was significantly higher than those of the control animals (387.6 and 85.5 mg/dl, respectively). BLPL was orally administered for 14 days in STZ-induced diabetic mice. Daily administration of the extracts for 14 days significantly reduced blood glucose levels of the diabetic mice (213 mg/dl), whereas glucose levels of the untreated diabetic mice were unchanged (404 mg/dl). Moreover, serum levels of alkaline phosphatase (ALT), aspartate aminotrasferase (AST), total cholesterol, and low-density lipoprotein (LDL) were significantly reduced in BLPL-treated mice comparing to the diabetic control. Oral administration with BLPL also reduced weight of thrombi in the arteriovenous shunt model of rat. In conclusion, our data suggest that fermented banaba leaf complex extracts can ameliorate diabetes, hyperlipidemia, and thrombogenesis.

목차

Abstract
1. Introduction
2. Experiment Materials and Methods
2.1. Cultivation Conditions for Manufacturing Liquid Spawn Cultures
2.2. Cultivation of P. linteus Mycelium in a Natural
2.3. Animals
2.4. Induction of Type 1 DM
2.5. Treatment of Diabetic Mice and Rats with BLPL and BLHE
2.6. Thrombus formation with an extracorporeal shunt
2.7. Di(phenyl)-(2,4,6-trinitrophenyl) Iminoazanium (DPPH) Radical Scavenging Activity
2.8. Statistical Analysis
3. Result and Discussion
3.1. Effects of the Banaba Leaf Extracts on STZ-Induced Diabetes in Rats and Mice
3.2. Effects of BLPL on Serum ALT, AST, Total Cholesterol, and Low Density Lipoprotein (LDL) Levels
3.3. Effects of BLPL on Thrombus Formation
3.4. Free Radical Scavenging Effects of BLPL
4. Discussion
5. Conclusion
Acknowledgments
References

키워드

Type 1 Diabetest Type 2 Diabetest Banaba Leaf Complex Extracts Fermentation Thrombosis Oxidative stress

저자

  • Hyun-Kyoung Kim [ Professor, Department of Food Science and Engineering, Seowon University, Cheongju, Korea ] Corresponding Author
  • Kyung-Won Ko [ CEO, Grokwon Corporation, Danyang-gun, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    국제인공지능학회(구 한국인터넷방송통신학회) [The International Association for Artificial Intelligence]
  • 설립연도
    2000
  • 분야
    공학>전자/정보통신공학
  • 소개
    인터넷방송, 인터넷 TV , 방송 통신 네트워크 및 관련 분야에 대한 국내는 물론 국제적인 학술, 기술의 진흥발전에 공헌하고 지식 정보화 사회에 기여하고자 한다.

간행물

  • 간행물명
    The International Journal of Advanced Smart Convergence
  • 간기
    계간
  • pISSN
    2288-2847
  • eISSN
    2288-2855
  • 수록기간
    2012~2025
  • 십진분류
    KDC 326 DDC 380

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