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Synthesis of Itraconazole and Diosgenin Encapsulated Niosomes and Analysis of Anti-cancer Activity in Human Colorectal Cancer Cell Lines (HCT–116)

첫 페이지 보기
  • 발행기관
    조선대학교 기초과학연구원 바로가기
  • 간행물
    통합자연과학논문집(구 조선자연과학논문집) KCI 등재후보 바로가기
  • 통권
    제17권 4호 (2024.12)바로가기
  • 페이지
    pp.141-155
  • 저자
    Karthik Bonthala, Aishwarya Shaile Talluri, Dharani K, Apala Pal, Sruthy Sathish, Bavya Chandrashekar, Thirumurthy Madhavan
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A461758

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원문정보

초록

영어
Human Colon Cancer is the third most common cancer worldwide accounting for about 10% of all cancer cases and the second leading cause of cancer deaths. Niosomes are utilized for targeted drug delivery to specific sites to achieve desired therapeutic effects with minimal side effects. Itraconazole and Diosgenin were selected as potential compounds in silico analysis of pharmacokinetic properties. Itraconazole is an antifungal medication used to treat various fungal infections. Diosgenin is a naturally occurring steroid saponin in various plants. Each of the compound loaded Niosomes were prepared using non-ionic surfactants and cholesterol along with the respective compound and the method used for preparation included thin film hydration using rotary evaporator and followed by sonication. The dynamic light scattering showed an average size of 343.8 nm for Itraconazole loaded niosomes and 194.3 nm for Diosgenin encapsulated niosomes. The encapsulation efficiency was shown to be 72.4% and 69% for Itraconazole and Diosgenin respectively for their niosomes. Cytotoxicity studies were performed and MTT Assay revealed an IC50 value indicated 53.84 μM and 45.8 μM for the compounds Itraconazole and Diosgenin and 36.58 μM and 59.58 μM for the respective loaded niosomes when administered in HCT116 colorectal cancer cell lines.

목차

Abstract
1. Introduction
2. Materials and methods
2.1. In silico analysis of short listed compounds
2.2. Nisome prepapation and encapsulation
2.3. Physicochemical haracterization of compound and niosomes
2.4. Cytotoxicity studies of compound and niosomes
3. Results
3.1. Recognition of potential drugsAmong 4000 prospective synthetic anticancer
3.2. ADMET prediction
3.3. cDFT analysis
3.4. UV Spectroscopy
3.5. Encapsulation efficiency
3.6. Particle size and zeta potential of niosomes
3.7. High resolution - transmission electronmicroscopy (HR-TEM)
3.8. FT-IR spectroscopy
3.9. MTT assay
4. Discussion
5. Conclusion
Acknowledgements
Conflict of interest
References

키워드

Colon Cancer Niosomes Targeted Drug Delivery Anticancer

저자

  • Karthik Bonthala [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Aishwarya Shaile Talluri [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Dharani K [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Apala Pal [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Sruthy Sathish [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Bavya Chandrashekar [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ]
  • Thirumurthy Madhavan [ Department of Genetic Engineering, Computational biology lab, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    조선대학교 기초과학연구원 [The Natural Science Research Institute of Chosun]
  • 설립연도
    2008
  • 분야
    자연과학>자연과학일반
  • 소개
    본 연구원은 기초과학을 진흥하기 위한 연구·교육 및 그 보급을 목적으로 한다. 이 목적을 달성하기 위하여 다음 각 호의 사업을 수행한다. 1. 기초과학 제 분야에 관한 조사와 연구 2. 기초과학에 관한 학술행사(학술대회, 학술세미나, 심포지엄, 초청강연회 등) 개최 3. 학문후속세대 및 일반인을 위한 기초과학 교육 4. 기관지『조선자연과학논문지』 발간 5. 『자연과학연구총서』, 『자연과학번역총서』 등 단행본 발간 6. 기타 본 연구원의 목적과 관련된 사업

간행물

  • 간행물명
    통합자연과학논문집(구 조선자연과학논문집) [Journal of Integrative Natural Science]
  • 간기
    계간
  • pISSN
    2005-1042
  • 수록기간
    2008~2025
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 405 DDC 505

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