Earticle

초록

영어

The purpose of this study was to investigate the effects of weight- and non–weight-bearing exercises on the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, corticospinal axon regrowth and regeneration- related proteins following spinal cord injury (SCI). Twenty-four male Sprague-Dawley rats were randomly divided into four groups: control group (n=6), SCI+sedentary group (SED, n=6), SCI+treadmill exercise group (TREAD, n=6), and SCI+swimming exercise group (SWIM, n=6). All rats in the SCI group were given the rest for 2 weeks after SCI, and then they were allowed to engage in low-intensity exercise for 6 weeks on treadmill device. Motor function (BBB score) was improved more in the SWIM group compared to the SED group at 3 and 6 weeks after SCI. The SWIM group also showed higher levels of axonal outgrowth in cor-ticospinal tract and increased expression of phosphorylated extracellular signal-regulated kinase, a marker of axonal regeneration in the dorsal horn of the caudal region, compared to the TREAD group. Additionally, the SWIM group significantly upregulated the expression of regenera-tion-related proteins. Our findings suggest that non–weight-bearing ex-ercise may be one of several rehabilitation methods for improving loco-motor function and corticospinal axon regeneration after SCI.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Spinal cord injury
Weight- and non–weight-bearing exercise program
Locomotor assessment
Immunofluorescence staining
Anterograde DiI tracing technique
Western blot analysis
Statistical analysis
RESULTS
BBB locomotor scale after SCI
CST axonal elongation after SCI
Expression of p-ERK1/2 in motor neuron after SCI
Expression of regeneration-related proteins after SCI
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Joo-In Yu [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613