Earticle

초록

영어

Ketamine analogues are one of the new psychoactive substances (NPS) that have recently been increasing in occurrence and causing social problems worldwide. One of these, 2-fluoro-2-oxo PCE, has also been detected more frequently in Korea recently. 2-fluoro-2-oxo PCE is known to exhibit hallucinogenic and dissociative effects by acting on N-methyl-D-aspartate (NMDA) receptors, similar to ketamine. In early 2024, a man who caused a traffic accident while driving, stated that he purchased and took ketamine. But 2-fluoro-2-oxo PCE was detected in his urine and seized items. In general, to detect narcotics in biological samples such as urine and hair, detection of parent drugs and metabolites is performed to exclude the possibility of sample contamination. However, for NPSs such as 2-fluoro-2-oxo PCE, metabolite research has not been sufficiently conducted. Therefore, we performed analysis of 2-fluoro-2-oxo PCE metabolites in urine using liquid chromatography/quadrupole time-of-flight mass spectrometry and MetabolitePilotTM software. The detected major metabolites of 2-fluoro-2-oxo PCE were a dehydrogenated form of the cyclohexanone ring (M163), an N-deethylated form (M144), and a form in which N-deethylation and dehydrogenation occurred simultaneously (M124). The metabolite of N-deethylated, hydroxylated, and glucuronide-conjugated form was also identified.

목차

Abstract
Ⅰ. 서론
Ⅱ. 실험방법
1. 시약 및 재료
2. 시료
3. 추출방법
4. 분석기기 및 조건
Ⅲ. 결과 및 고찰
Ⅳ. 결론
Ⅴ. 사사
Ⅵ. 참고문헌

키워드

저자

• 조병석 [ Byungsuk Cho | 대전과학수사연구소 독성화학과 감정관 ]
• 연성훈 [ Sunghoon Yeon | 대전과학수사연구소 독성화학과 감정관 ]
• 우상희 [ Sanghee Woo | 대전과학수사연구소 독성화학과 감정관 ]
• 김동우 [ Dongwoo Kim | 대전과학수사연구소 독성화학과 감정관 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국법과학회지 [Korean Journal of Forensic Science]

• 간기

  반년간

• pISSN

  1598-0715

• 수록기간

  2000~2025

• 등재여부

  KCI 등재

• 십진분류

  KDC 367 DDC 347