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Effect of Taxifolin-3-O-arabinopyranoside from root extract of Korean Rhododendron mucronulatum on anti-hair loss

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2022 International symposium of Institute of Forest Science for the 40th Anniversary of College of Forest and Environment Science (2022.10)바로가기
  • 페이지
    pp.120-120
  • 저자
    Tae Hee Kim, Sun-Eun Choi
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450489

원문정보

초록

영어
In this study, hair growth and maintenance efficacy of root extract of Rhododendron mucronulatum Turcz. was confirmed using hair follicle dermal papilla cells (HFDPC). The root extract of Rhododendron mucronulatum Turcz. was divided into two types: an extract level of 60% alcohol extract (RMR60E) and a compound level of Taxifolin-3-O-arabinopyranoside (Taxifolin glycoside). Prior to the experiment, MTT assay was performed to confirm the cytotoxicity of RMR60E and Taxifolin glycoside, both of which showed cell viability of more than 80% in all concentration ranges (25~200μg/ml) used in the experiment, confirming that there was no toxicity. Afterwards, in the H2O2-induced apoptosis inhibitory effect test, it was confirmed that both RMR60E and Taxifolin glycoside increased the cell viability in a concentration-dependent manner. DHT assay was performed to confirm the ability to inhibit the production of dihydrotestosterone (DHT), which is the cause of male pattern hair loss. First, when 20 nM of testosterone was treated in HFDPC, the production of DHT was increased. Thereafter, when treated with minoxidile, a positive control, strong inhibitory activity was confirmed. In comparison, when treated with RMR60E and Taxifolin glycoside, it didn’t show a stronger inhibitory activity than minoxidile, but it was confirmed that DHT production was inhibited in a concentration-dependent manner when compared with the negative control group. Based on the results of this study, it is considered that extract of Rhododendron mucronulatum has the potential to be developed as a material for hair-loss related medicines, functional foods, and functional cosmetics.

키워드

Taxifolin-3-O-arabinopyranoside Anti-hair loss effect Hair follicle dermal papilla cells Dihydrotestosterone assay Apoptosis inhibitory effect

저자

  • Tae Hee Kim [ Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University ]
  • Sun-Eun Choi [ Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

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