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Cellulose nanocrystal-donepezil HCl gel structure for sustained drug release

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2022 International symposium of Institute of Forest Science for the 40th Anniversary of College of Forest and Environment Science (2022.10)바로가기
  • 페이지
    pp.70-70
  • 저자
    Da In Jeong, Sungyun Kim, Min-Hwan Kim, In-Soo Yoon, Seung-Hwan Lee, Dae-Duk Kim, Hyun-Jong Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450446

원문정보

초록

영어
Cellulose nanocrystal (CNC) hydrogel structure aggregated with donepezil hydrochloride (DPZ) and pH control was designed for long-acting drug delivery. By introducing cationic DPZ molecule into the CNC dispersion, the electrostatic repulsion force was reduced and viscoelasticity was modulated. Adjustment of pH value to 7.7 (in cCNC/DPZ gel) by the addition of NaOH to CNC/DPZ gel further increased viscoelastic properties. The cCNC/DPZ gel also showed single syringe injection and shear-thinning behavior. Moreover, the sustained release profile of DPZ from cCNC/DPZ gel was demonstrated. In the pharmacokinetic study in rats, the subcutaneous injection of cCNC/DPZ gel provided lower maximum DPZ concentration, longer half-life, and higher mean residence time values compared to those of DPZ solution and CNC/DPZ groups. These results support that the designed cCNC/DPZ gel can be safely used for sustained delivery of DPZ following its subcutaneous injection.

키워드

Cellulose nanocrystal Donepezil hydrochloride Hydrogel Subcutaneous injection Sustained release

저자

  • Da In Jeong [ Department of Pharmacy, College of Pharmacy, Kangwon National University ]
  • Sungyun Kim [ Department of Pharmacy, College of Pharmacy, Kangwon National University ]
  • Min-Hwan Kim [ College of Pharmacy and Research Institute of Pharmaceutical sciences, Seoul National University ]
  • In-Soo Yoon [ Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University ]
  • Seung-Hwan Lee [ Institute of Forest Science, Kangwon National University; Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea ]
  • Dae-Duk Kim [ College of Pharmacy and Research Institute of Pharmaceutical sciences, Seoul National University ]
  • Hyun-Jong Cho [ Department of Pharmacy, College of Pharmacy, Kangwon National University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

이 권호 내 다른 논문 / 강원대학교 산림과학연구소 학술대회 2022 International symposium of Institute of Forest Science for the 40th Anniversary of College of Forest and Environment Science

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