Earticle

현재 위치 Home

Biodegradable 3D-printed self-standing scaffolds of cellulose nanocrystals reinforced chitosan/silk fibroin for improved bone regeneration

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2021 International Symposium of Institute of Forest Science (2021.10)바로가기
  • 페이지
    pp.19-19
  • 저자
    Dinesh K. Patel, Ki-Taek Lim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450405

원문정보

초록

영어
3D-printed biodegradable cellulose nanocrystal (CNC)-reinforced chitosan/silk fibroin scaffolds were synthesized as an advanced material for regenerative medicine application. The developed bio-inks were characterized using Fourier transform infrared spectroscopy and X-ray diffraction analysis. The composite scaffolds exhibited better swelling potential and better degradation potential than the pure polymer scaffolds. The cytotoxicity of the developed scaffolds was measured using the WST-1 assay in the presence of human bone marrow-derived mesenchymal stem cells (hMSCs). Improved cell viability and mineral deposition were observed with composite scaffolds vis-à-vis pure polymer scaffolds, showing their improved biocompatibility and mineralization potential. Upregulation of osteogenic associated gene markers was observed in the composite scaffold-treated media compared to the control, indicating enhanced osteogenic efficiency. The osteogenic induction process occurs via the mitogen-activated protein kinase pathway. Higher M1 macrophages polarization occurred in the scaffolds treated media after 24 h of incubation, which assisted the angiogenesis in bone tissue regeneration during the initial stage. Moreover, shifting from M1 to M2 macrophages polarization was observed in the scaffolds treated media after 3 days of incubation, suggesting its tissue regeneration potential. Compared to the control group, enhanced bone regeneration was observed in the calvaria defect rat model with the printed scaffolds, indicating their superior osteogenic efficiency. These results demonstrate that the printed scaffolds are promising materials for vascularized bone-healing applications and provide practical approaches for biomaterial development.

키워드

Celluloce nanocrystals 3D-printing Osteogenesis Macrophages Bone regeneration

저자

  • Dinesh K. Patel [ Department of Biosystems Engineering, Institute of Forest Science, Kangwon National University ]
  • Ki-Taek Lim [ Department of Biosystems Engineering, Institute of Forest Science, Kangwon National University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

이 권호 내 다른 논문 / 강원대학교 산림과학연구소 학술대회 2021 International Symposium of Institute of Forest Science

    피인용수 : 0건 (자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      출처 : 네이버학술정보

        0개의 논문이 장바구니에 담겼습니다.

        페이지 저장
        소속기관 조회
        이용자님의 소속기관(단체)이 서비스에 가입되어 있는지 확인해 보십시오.
        기관회원에 소속되어 있는 이용자는 원문을 무료로 이용할 수 있습니다.