Earticle

현재 위치 Home

The development of gene carrier using cellulose nanocrystal and Zinc-DNA combination systems

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    KNU IFS 2018 Annual International Symposium of Institute of Forest Science (2018.09)바로가기
  • 페이지
    pp.103-103
  • 저자
    Jihyeon Lee, Hanjin Yu, Kwang Suk Lim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450215

원문정보

초록

영어
To effectively delivery of nucleic acids into the cells, various gene delivery systems are required. They protect nucleic acids against immune response, serum, and elimination mechanism. Nonviral gene delivery systems have low immune response, low side effect and temporary transfection compared with viral systems. Cellulose nanocrystal (CNC) is widely used as biomedical materials because of its good mechanical properties due to their lower weight, bbiocompatibility and biodegradability. In this study, we determined that CNC-Zinc/DNA combination systems (CZD cluster) could be deliver nucleic acids into the cells. CZD cluster successfully retarded migration of nucleic acids in agarose gel and enhanced DNA transfection efficiency into the cells. CZD cluster was spontaneously formed without any chemical reaction. This cluster systems could be used to deliver any plasmid DNA or siRNA in the cells and tissues without the requirement for a specific modification of the nucleic acids.

키워드

Gene delivery Cellulose Nanocrystal Nano-complex Zinc

저자

  • Jihyeon Lee [ Department of Biotechnology and Bioengineering, College of Engineering, Kangwon National University ]
  • Hanjin Yu [ Department of Biotechnology and Bioengineering, College of Engineering, Kangwon National University ]
  • Kwang Suk Lim [ The Institute of forest science, Kangwon National University, Chuncheon-si, 24341, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

이 권호 내 다른 논문 / 강원대학교 산림과학연구소 학술대회 KNU IFS 2018 Annual International Symposium of Institute of Forest Science

    피인용수 : 0(자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      페이지 저장