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The protective effect of quercetin on the oxidative stress-induced substances in H9c2 cells

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    KNU IFS 2018 Annual International Symposium of Institute of Forest Science (2018.09)바로가기
  • 페이지
    pp.102-102
  • 저자
    Hanjin Yu, Jihyeon Lee, Kwang Suk Lim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450214

원문정보

초록

영어
Over-expression of reactive oxygen species (ROS) in the tissues lead to diabetic complications such as cardiac dysfunction, diabetic nephropathy and endothelial dysfunction. Pharmaceutical agents are required for the treatment and prevent of these complications. Quercetin is a polyphenol flavonoid, which is widely found in vegetables, grains and fruits, and is known for its antioxidant activity against oxidative stress. In this study, we determined that quercetin protected H9c2 cells against oxidative stress. To induce ROS in the cell, H9c2 cells were exposed to hydrogen peroxide (H2O2), hyperglycemia and sodium arsenite (NaAsO2). These materials were decreased the cell viability of H9c2 cells by oxidative stress induced time and concentration dependent. Quercetin strongly protected H9c2 cells under the stressful conditions by reducing intracellular ROS level and inhibiting apoptosis pathway. Quercetin may be useful therapeutic component for the treatment or prevention of myocardial infarction.

저자

  • Hanjin Yu [ Department of Biotechnology and Bioengineering, College of Engineering, Kangwon National University, Chuncheon-si, 24341, Republic of Korea ]
  • Jihyeon Lee [ Department of Biotechnology and Bioengineering, College of Engineering, Kangwon National University, Chuncheon-si, 24341, Republic of Korea ]
  • Kwang Suk Lim [ The Institute of forest science, Kangwon National University, Chuncheon-si, 24341, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

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