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Preparation of liposomes bearing H2O2-responsive polymer and its H2O2-triggerable release property
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- 발행기관
- 강원대학교 산림과학연구소 바로가기
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- 간행물
- 강원대학교 산림과학연구소 학술대회 바로가기
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- 통권
- KNU IFS 2018 Annual International Symposium of Institute of Forest Science (2018.09)바로가기
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- 페이지
- pp.94-94
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A450206
원문정보
초록
- 영어
- H2O2-triggerable liposomes were prepared by modifying the liposome surface with an H2O2-responsive polymer. DOPE liposomes can be formed by incorporating amphiphilic polymer. The polymer was synthesized by a free radical reaction. Polymerization was confirmed by 1H-NMR, and FT-IR. The degree of surface activity of the polymers was also examined. As a result of the polymer characterization, the polymer was measured amphiphilic. Liposomes were prepared by varying the content of the polymer. The quenching degree of the liposome was confirmed to be about 46.2% to 57.7%. Liposome morphology was observed with a TEM microscope. As the weight ratio of polymer to DOPE lipid increased, the average diameter of liposome increased and triggerable release of calcein. When H2O2 concentration was 0%, 1.5%, 3.0%, and 6.0%, the DOPE to polymer ratio of 200:1 liposome release about 0.5%, 50.8%, 78.0%, and 78.4%, respectively. DOPE liposome with polymer 200:4 was more susceptible to H2O2 and showed 80% release within 20 seconds.
키워드
DOPE liposome H2O2-triggerable저자
간행물 정보
발행기관
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- 발행기관명
- 강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
- 설립연도
- 1975
- 분야
- 농수해양>임학
- 소개
- 강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.
간행물
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- 간행물명
- 강원대학교 산림과학연구소 학술대회
- 간기
- 부정기
- 수록기간
- 2017~2024
- 십진분류
- KDC 526 DDC 634
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