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Multi stimuli-sensitive drug delivery system using poly(ethyleneimine)/cinnamic acid

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    KNU IFS 2018 Annual International Symposium of Institute of Forest Science (2018.09)바로가기
  • 페이지
    pp.3-3
  • 저자
    Danbi Park, Jin-Chul Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450132

원문정보

초록

영어
Multi stimuli-sensitive drug delivery system using poly(ethyleneimine)(PEI) and cinnamic acid(CA) was prepared by self-assembly. PEI and CA are combined by electrostatic attraction to form a conjugate. Since PEI is hydrophilic and CA is hydrophobic, the conjugate exhibits amphipathic properties. Thus, the conjugate forms a self-assembly in aqueous solution. The formed self-assembly is characterized by its response to various stimuli (pH, temperature, UV). In the case of pH, PEI/CA forms a self-assembly at acidic pH. However, as the pH increases, the degree of ionization of PEI decreases, and the electrostatic attraction between PEI and CA decreases so that the self-assembly is disassembled. In the case of temperature, PEI/CA forms a self-assembly at room temperature, but when the temperature increases, the PEI/CA conjugate decreases in amphipathicity as the solubility of CA increases, self-assembly is disassembled. In the case of UV, when UV light is applied to the self-assembly, CA is isomerized from trans to cis and the self-assembly is disassembled. The self-assembly having the multi stimuli-sensitive characteristic can be applied to the cubic phase, which is a lipid structure. In addition, gold nanoparticle (GNP) representing the surface plasmon resonance phenomenon can be added to the cubic phase to give a response characteristic to NIR. The cubic phase consists of lipid bilayer and water channel. The self-assembly is contained on the water channel and the GNP is inserted into the lipid bilayer. When the NIR are irradiated on the cubic phase, the solubility of CA is increased because the GNP generates heat due to the surface plasmon resonance. As a result, the self-assembly which blocks the inside of the water channel of cubic phase is disassembled and the contents are released.

키워드

Poly(ethyleneimine) Cinnamic Acid pH-Sensitive Temperature-Sensitive UV-Sensitive NIR-Sensitive

저자

  • Danbi Park [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University ]
  • Jin-Chul Kim [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

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