Earticle

초록

영어

Stress during pregnancy has a negative effect on the fetus. However, maternal exercise has a positive effect on the cognitive function of the fetus and alleviates the negative effects of stress. This study aimed to demonstrate whether exercise before pregnancy has a protective ef-fect on prenatal stress-induced impairment of memory, neurogenesis and mitochondrial function in mice offspring. In this experiment, immu-nohistochemistry, Western blot, measurement of mitochondria oxygen respiration, and behavior tests were performed. Spatial memory and short-term memory of the offspring from the prenatal stress with exer-cise were increased compared to the offspring from the prenatal stress. The numbers of doublecortin-positive and 5-bromo-2’-deoxyuridine- positive cells in the hippocampal dentate gyrus of the offspring from the prenatal stress with exercise were higher compared to the offspring from the prenatal stress. The expressions of brain-derived neurotrophic factor, postsynaptic density 95 kDa, and synaptophysin in the hippo-campus of the offspring from the prenatal stress with exercise were enhanced compared to the offspring from the prenatal stress. Oxygen consumption of the offspring from the prenatal stress with exercise were higher compared to the offspring from the prenatal stress. Exer-cise before pregnancy alleviated prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function. Therefore, exercise before pregnancy may have a protective effect against prenatal stress of the offspring.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
Exercise protocol before pregnancy
Stress exposure to pregnant mice
Elevated plus maze test
Morris water maze task
Step-through avoidance task
Doublecortin immunohistochemistry
5-bromo-2’-deoxyuridine immunohistochemistry
Western blotting for brain-derived neurotrophic factor, postsynaptic density 95 kDa, and synaptophysin
Measurement of mitochondria oxygen respiration
Data analysis
RESULTS
Behavioral tests
DCX and BrdU-positive cells in the dentate gyrus
BDNF, PSD-95, and synaptophysin expression in the hippocampus
Mitochondrial oxygen respiration in the hippocampus
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ]
• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Hoon Kim [ Department of Sport and Health Sciences, College of Art and Culture, Sangmyung University, Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA ]
• Myung-Ki Kim [ College of Culture and Sports, Division of Global Sport Studies, Korea University, Sejong, Korea ]
• Mal-Soon Shin [ College of Culture and Sports, Division of Global Sport Studies, Korea University, Sejong, Korea ]
• Seong-Hyun Kim [ Department of Kinesiology, Michigan State University, East Lansing, MI, USA ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613