Earticle

초록

영어

The aim of this study was to determine whether walking exercise can regulate the expression level of neuropathic pain- and inflammatory re-sponse markers in the ipsilateral lumbar 4 to 6 dorsal root ganglion neu-rons after sciatic nerve injury (SNI). The experimental rats were ran-domly divided into seven groups: the normal control group, sedentary groups for 3, 7, and, 14 days postinjury (dpi), and walking exercise groups for 3, 7, and 14 dpi. Western blot techniques were used to evaluate spe-cific neuropathic pain- and cytokine markers and mechanical allodynia was confirmed by paw withdrawal test. Mechanical allodynia was sig-nificantly improved in the walking exercise group compared to the sed-entary group at all 7, 10, and 14 dpi. Furthermore, growth associated protein 43 and brain-derived neurotrophic factor levels were signifi-cantly increased in the walking exercise groups compared to the sed-entary group at all 3, 7, and 14 dpi. Conversely, nuclear factor kappa-light-chain-enhancer of activated B cells, interleukin-6, tumor necrosis factor α, calcitonin gene-related peptide, and c-Fos expression levels were significantly decreased in the walking exercise groups compared to the sedentary group at all 3, 7, and 14 dpi. These findings suggest meaning-ful information that aggressive rehabilitation walking exercise applied early after SNI might be improve mechanical allodynia, neuropathic pain and inflammatory response markers following SNI.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Sciatic nerve injury protocol
Walking exercise protocol
Western blot analysis
Paw withdrawal test
Statistical analysis
RESULTS
The walking exercise improved mechanical allodynia after SNI
The walking exercise increased induction of nerve regeneration proteins in the in ipsilateral DRGs
The walking exercise decreased levels of NP proteins in the in ipsilateral DRGs
The walking exercise decreased induction of inflammatory markers in the in ipsilateral DRGs
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Yeong-Hyun Cho [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613