Earticle

초록

영어

Doxorubicin (DOX) is a widely used chemotherapy drug for various cancers and it is known to induce cognitive impairment. The aim of this study was to investigate the effect of treadmill exercise on chemother-apy-induced memory impairment. We assessed whether DOX affects inflammation, mitochondrial Ca2+ retention capacity, and Wnt/β-catenin signaling. Male Sprague-Dawley rats were divided into control group, exercise group, DOX-injection group, and DOX-injection and exercise group. To create a DOX-induced memory impairment model, animals were injected intraperitoneally with DOX (2 mg/kg) dissolved in saline solution once a week for 4 weeks. Treadmill exercise was performed once a day, 5 days a week, for 8 consecutive weeks. Short-term memo-ry was determined using the step-down avoidance test. Western blot was performed for the proinflammatory cytokines, Wnt/β-catenin sig-naling, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) in the hippocampus. Mitochondrial Ca2+ retention ca-pacity in the hippocampus was also measured. DOX-injection rats showed deterioration of short-term memory along with decreased ex-pression of BDNF and TrkB in the hippocampus. Levels of the proinflam-matory cytokines, tumor necrosis factor-α and interleukin-6, were in-creased in the DOX-injection rats. Wnt/β-catenin signaling was activat-ed and mitochondrial Ca2+ retention capacity was decreased in the DOX-injection rats. However, treadmill exercise alleviated short-term memory impairment, decreased proinflammatory cytokines, increased BDNF and TrkB expression, and enhanced mitochondrial Ca2+ retention capacity. Treadmill exercise restorated Wnt/β-catenin signaling path-way. This study demonstrated that treadmill exercise can be used for patients undergoing chemotherapy with DOX.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
DOX-induced memory impairment
Exercise protocol
Step-down avoidance test
Concentrations of proinflammatory cytokines
Western blotting
Mitochondria Ca2+ retention capacity
Data analysis
RESULTS
Short-term memory
TNF-α and IL-6 concentrations
Wnt and β-catenin expressions
BDNF and TrkB expressions
Mitochondrial Ca2+ retention capactity
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Hoon Kim [ Department of Sport and Health Sciences, College of Art and Culture, Sangmyung University, Seoul, Korea, Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA ]
• Bo-Kyun Kim [ Department of Emergency Technology, College of Health Science, Gachon University, Incheon, Korea ]
• Mal-Soon Shin [ Division of Global Sport Studies, College of Culture and Sports, Korea University, Sejong, Korea ]
• Hyun-Tae Jeong [ Division of Global Sport Studies, College of Culture and Sports, Korea University, Sejong, Korea ]
• Jong-Suk Park [ Division of Global Sport Studies, College of Culture and Sports, Korea University, Sejong, Korea ]
• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613