Earticle

초록

영어

Background: This study has mainly focused on finding pharmacological effects of ginsenosides that can reduce the unwanted side effects of the cytotoxic anticancer drugs and are highly effective on prostate cancer, colorectal cancer, liver cancer, hormone-dependent breast cancer, triple-negative breast cancer, and brain cancer (neuroblastoma). Methods: Minor and rare ginsenosides (GS) of Rh2 which have a high absorption ability and excellent pharmacological actions were treated with the 6 different types of cancer cell lines and their anticancer activities were investigated by analyzing gene expressions associated with various cancers through qPCR and other relevant methods. Results: In cancer cells exposed to Rh2, cell viability and cell migration were reduced, and apoptosis was induced. Each cancer cell was divided into three groups according to the cell proliferation response by Rh2; 1) A group in which the cell viability decreases inversely to an increase in Rh2 treatment concentration; 2) A group in which the cell viability rapidly decreases in Rh2 treatment above a certain level of concentration; 3) A group in which the cell viability was not suppressed below 20-30% even with 100 μL of Rh2, the highest concentration used in this study. Conclusions: It was shown that Rh2 has a significant effect on inhibiting the proliferation of prostate cancer cells and hormone-dependent breast cancer cells.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Rh2
Cell culture and GS treatments
Cell viability and IC50 assay
Cell migration assay
Florescence analysis of apoptosis/necrosis
Statistical analysis
RESULTS
Cell viability
Apoptosis and necrosis analysis
DISCUSSION
REFERENCES

키워드

저자

• Seun Eui Kim [ Genuine Research, Department of Biotechnology, Hankyong National University, Ansung 17579, Korea ]
• Myoung-Hoon Lee [ Genuine Research, Seoul 06040, Korea ]
• Hye-Myoung Jang [ Genomic Informatics Center, Hankyong National University, Ansung 17579, Korea ]
• Wan-Taek Im [ Department of Biotechnology, Hankyong National University, Ansung 17579, Korea ]
• Joontaik Lee [ Department of Biotechnology, Hankyong National University, Ansung 17579, Korea ]
• Sang-Hwan Kim [ School of Animal Life Convergence Science, Hankyong National University, Ansung 17579, Korea ]
• Gwang Joo Jeon [ Department of Biotechnology, Hankyong National University, Genomic Informatics Center, Hankyong National University, Ansung 17579, Korea ] Corresponding Author

참고문헌

발행기관

간행물

관심저널 등록

• 간행물명

  Journal of Animal Reproduction and Biotechnology

• 간기

  계간

• pISSN

  2671-4639

• eISSN

  2671-4663

• 수록기간

  2019~2025

• 십진분류

  KDC 527 DDC 636