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Original Article

Therapeutic Duplication as a Medication Error Risk in Fixed-Dose Combination Drugs for Dyslipidemia : A Nationwide Study

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  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제33권 제3호 (2023.08)바로가기
  • 페이지
    pp.168-177
  • 저자
    Wonbin Choi, Hyunji Koo, Kyeong Hye Jeong, Eunyoung Kim, Seung-Hun You, Min-Taek Lee, Sun-Young Jung
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A435566

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원문정보

초록

영어
Background & Objectives: Fixed-dose combinations (FDCs) offer advantages in adherence and cost-effectiveness compared to free combinations (FCs), but they can also complicate the prescribing process, potentially leading to therapeutic duplication (TD). This study aimed to identify the prescribing patterns of FDCs for dyslipidemia and investigate their associated risk of TD. Methods: This was a retrospective cohort study involving drugs that included statins, using Health Insurance Review & Assessment Service- National Patient Sample (HIRA-NPS) data from 2018. The unit of analysis was a prescription claim. The primary outcome was TD. The risk ratio of TD was calculated and adjusted for patient, prescriber, and the number of cardiovascular drugs prescribed using a multivariable Poisson model. Results: Our study included 252,797 FDC prescriptions and 515,666 FC prescriptions. Of the FDC group, 46.52% were male patients and 56.21% were aged 41 to 65. Ezetimibe was included in 71.61% of the FDC group, but only 0.25% of the FC group. TD occurred in 0.18% of the FDC group, and the adjusted risk ratio of TD in FDC prescriptions compared to FC was 6 . 44 (95% CI 5 . 30-7. 82). Conclusions: Prescribing FDCs for dyslipidemia was associated with a higher risk of TD compared to free combinations. Despite the relatively low absolute prevalence of TD, the findings underline the necessity for strategies to mitigate this risk when prescribing FDCs for dyslipidemia. Our study suggests the potential utility of Clinical Decision Support Systems and standardizing nomenclature in reducing medication errors, providing valuable insights for clinical practice and future research.

목차

ABSTRACT
Methods
Data source and study design
Exposure and potential confounders
Outcome
Statistical methods
Results
Descriptive statistics
Therapeutic duplication associated with fixed-dose combinations
Discussion
Conclusion
Acknowledgments
Conflicts of Interest
References

키워드

Drug prescriptions dyslipidemias fixed-dose combination drugs medication errors therapeutic duplication

저자

  • Wonbin Choi [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Hyunji Koo [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Kyeong Hye Jeong [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Eunyoung Kim [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Seung-Hun You [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Min-Taek Lee [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Sun-Young Jung [ College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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