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Antioxidant, anticancer, and wound-healing properties of roridin E isolated from mycelial culture medium of Podostroma cornudamae mushroom

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 KCI 등재 바로가기
  • 통권
    제21권 제2호 (2023.06)바로가기
  • 페이지
    pp.33-40
  • 저자
    Si Young Ha, Dong Hwan Lee, Ji Young Jung, Han Min Park, Jae-Kyung Yang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A433439

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원문정보

초록

영어
Roridin E, a constituent of Podostroma cornu-damae, has excellent medicinal properties and exhibits powerful anticancer effects. However, being a poisonous mushroom, P. cornu-damae is difficult to find in its natural environment. Therefore, only a limited amount of roridin E is isolated from P. cornu-damae. We isolated roridin E from mycelial culture medium of P. cornu-damae and examined its effects on five breast cancer cell lines. The purity of the isolated roridin E was 96%. It exhibited anticancer effects on all five breast cancer cell lines, with an IC50 of at least 0.0006 mg/L. To the best of our knowledge, this is the first report on the investigation of effects of roridin E isolated from the mycelium of P. cornu-damae mushrooms on five breast cancer cell lines. However, safety issues should be investigated and addressed in future studies before roridin E is used in clinical settings.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Microorganism
Submerged culture
Extract and isolation of roridin E
Analytical TLC and UV-Visible spectroscopy
High pressure liquid chromatography analysis
Antioxidant properties
Cell lines and culture
The MTT cell viability assay for cytotoxicity testing
Scratch wound healing assay
RESULTS AND DISCUSSION
Isolation of roridin E from P. cornu-damae culture broth
Characterization of the isolated compound used UVVisiblespectroscopy
HPLC spectrum of isolated roridin E
Antioxidant activity of isolated roridin E
Anticancer activity of isolated roridin E
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES

저자

  • Si Young Ha [ Department of Environmental Materials Science/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ]
  • Dong Hwan Lee [ Forest Medicinal Resources Research Center, National Institute of Forest Science, Youngju 36040, Republic of Korea ]
  • Ji Young Jung [ Department of Environmental Materials Science/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ]
  • Han Min Park [ Department of Environmental Materials Science/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ]
  • Jae-Kyung Yang [ Department of Environmental Materials Science/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

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