Objectives: This gender comparative study aimed to analyze the risk factors of cardiovascular disease, which causes sudden cardiac death, in individuals living alone. Methods: It assessed 338 people within 30-74 years of age, living in one-person households, obtained from the 8th National Health and Nutrition Examination Survey. Cardiovascular risk assessment estimated age, systolic pressure, smoking, BMI and diabetes. Results: Significant predictors of cardiovascular risk were; education and household income (common), physical activity (male 10%), toothache (male 20%), dyslipidemia (male 10%, 20%; female 10%), calories (male 20%) and carbohydrates (male 10%). Conclusions: The differences in cardiovascular risk predictors between the groups indicate that intervention using by various approaches are necessary.