Earticle

현재 위치 Home

Research Article

Effect of Cordyceps militaris mycelia containing improved cordycepin on expression gene in the melanin biosynthesis pathway

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 KCI 등재 바로가기
  • 통권
    제21권 제1호 (2023.03)바로가기
  • 페이지
    pp.8-14
  • 저자
    Si Young Ha, Ji Young Jung, Jae-Kyung Yang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A427769

※ 기관로그인 시 무료 이용이 가능합니다.

4,000원

원문정보

초록

영어
This study aimed to verify the whitening effect of Cordyceps militaris, which is distributed in several countries worldwide, including Korea, Japan, and China, and has various medical effects. To screen the efficacy of C. militaris, the inhibitory activity of tyrosinase, which was 66% at a concentration of 1 mg/mL, was measured. Thereafter, the survival rate of melanoma cells was measured, and cell experiments were conducted at a concentration of 90% or more in which C. militaris was not toxic to cells. After measuring the inhibitory effect of TRP-1, TRP-2, tyrosinase protein, and mRNA expression, which are factors influencing melanin synthesis, C. militaris was found to decrease in all factors, with an expression level that was significantly lower compared to quercetin. This confirmed that C. militaris stimulated with LED has excellent whitening activity and can be used as a functional whitening cosmetics material.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Fungal strains
Submerged culture conditions
Cell culture
Cell viability assay
Tyrosinase activity assay
Melanin content assay
Investigation of genes
Investigation of protein expression
RESULTS AND DISCUSSION
Cell viability of melanoma cells induced by C. militaris mycelia
Inhibition mushroom tyrosinase activity of C. militaris mycelia
Effect of C. militaris mycelia on melanin content in B16F10 cells
Genetic investigation
Investigation of protein expression
CONCLUSION
Acknowledgements
Data Availability
Conflicts of Interest
Authors Contributions
REFERENCES

키워드

Cordyceps militaris Gene expression LED Melanin Tyrosinase

저자

  • Si Young Ha [ Department of Environmental Materials Science, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ]
  • Ji Young Jung [ Department of Environmental Materials Science, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ]
  • Jae-Kyung Yang [ Department of Environmental Materials Science, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2025
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

이 권호 내 다른 논문 / 한국버섯학회지 제21권 제1호

    피인용수 : 0(자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      페이지 저장