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Original Article

Comparison of Fentanyl-Based Rapid Onset Opioids for the Relief of Breakthrough Cancer Pain : Drug Price Based on Effect Size

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제33권 제1호 (2023.03)바로가기
  • 페이지
    pp.43-50
  • 저자
    Seongchul Kim, Hayoun Jung, Jina Park, Jinsol Baek, Yeojin Yun, Junghwa Hong, Eunyoung Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A427757

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원문정보

초록

영어
Background and Objective: With the advancement of cancer treatments and increased life expectancy, managing breakthrough cancer pain (BTcP) is essential to improve the quality of life for cancer patients. This study aimed to compare the major rapid onset opioids in Korea based on their characteristics and costs to determine the best option for each patient. Methods: Based on sales information from IQVIA-MIDAS, sublingual fentanyl tablet (SLF), fentanyl buccal tablet (FBT), and oral transmucosal fentanyl citrate (OTFC) were selected as the top three drugs for the treatment of BTcP in Korea, considering them the most comparable drugs. The cost and cost-pain relief ratio of the drugs for short-term (1 month) and long-term (1 year) treatment were compared and the ease of administration based on various factors, including pharmacokinetics, onset of action, and administration procedures were evaluated. Results: SLF was evaluated as the best overall in terms of rapid onset of action, ease of administration, and drug cost and also had the highest market share. SLF had the lowest cost pain relief ratio for both the initial and supplemental treatment for the 1- month pain intensity difference 15 (PID15) ratio. However, for the 1-month PID30 ratio, SLF was not superior to OTFC or FBT. The longer the breakthrough cancer pain duration, the more cost-effective the other rapid onset opioids. Conclusion: The rapid onset opioids that fit the patient’s breakthrough cancer pain pattern have the best cost-effectiveness.

목차

ABSTRACT
Materials and Methods
Selection of drugs for research
Literature search
Comparison
Results
Comparison of characteristics and drug cost
Comparison of cost pain relief ratio
Ease of administration
Discussion
Conclusion
Conflicts of Interest
References

키워드

Breakthrough cancer pain rapid onset opioids

저자

  • Seongchul Kim [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Hayoun Jung [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Jina Park [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Jinsol Baek [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Yeojin Yun [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Junghwa Hong [ Department of Pharmaceutical Industry, Chung-Ang University, Seoul 06974, Republic of Korea ]
  • Eunyoung Kim [ Department of Pharmaceutical Industry, Chung-Ang University, Clinical Data Analysis, Evidence-Based Clinical Research Laboratory, Departments of Health Science & Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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