Earticle

초록

영어

Background: Aptamers are currently being used in various fields including medical treatments due to their characteristics of selectively binding to specific molecules. Due to their special characteristics, the aptamers are expected to be used to remove radionuclides from a large amount of liquid radioactive waste generated during the decommissioning of nuclear power plants. The radiological effects on the aptamers should be evaluated to ensure their integrity for the application of a radionuclide removal technique. Materials and Methods: In this study, Monte Carlo N-Particle transport code version 6 (MCNP6) and Monte Carlo damage simulation (MCDS) codes were employed to evaluate the radiological effects on the aptamers. MCNP6 was used to evaluate the secondary electron spectrum and the absorbed dose in a medium. MCDS was used to calculate the DNA damage by using the secondary electron spectrum and the absorbed dose. Binding experiments were conducted to indirectly verify the results derived by MCNP6 and MCDS calculations. Results and Discussion: Damage yields of about 5.00×10-4 were calculated for 100 bp aptamer due to the radiation dose of 1 Gy. In experiments with radioactive materials, the results that the removal rate of the radioactive 60Co by the aptamer is the same with the non-radioactive 59Co prove the accuracy of the previous DNA damage calculation. Conclusion: The evaluation results suggest that only very small fraction of significant number of the aptamers will be damaged by the radioactive materials in the liquid radioactive waste.

목차

ABSTRACT
Introduction
Materials and Methods
1. Liquid Waste Generation Scenarios Applied to the Evaluation
2. DNA Damage Evaluation Using MCNP6 and MCDS
3. Binding Experiments between Aptamer-Bead Complex and Ionic Nuclides
Results and Discussion
1. DNA Damage in a Cell
2. Aptamers Damage in a Cell
3. Aptamers Damage in Liquid Waste
4. Aptamers Damage per Absorbed Dose
5. Evaluation Results of Removal Rates of Nuclides (59Co/60Co) by the Binding Experiments
Conclusion
Conflict of Interest
Acknowledgements
Ethical Statement
Author Contribution
References

키워드

저자

• Minhye Lee [ RADCORE, Co., Ltd., Daejeon, Korea ]
• Gilyong Cha [ RADCORE, Co., Ltd., Daejeon, Korea ]
• Dongki Kim [ RADCORE, Co., Ltd., Daejeon, Korea ]
• Miyong Yun [ Sejong University, Seoul, Korea ]
• Daehyuk Jang [ Sejong University, Seoul, Korea ]
• Sunyoung Lee [ Sejong University, Seoul, Korea ]
• Song Hyun Kim [ Kepco International Nuclear Graduate School, Ulsan, Korea ]
• Hyuncheol Kim [ Korea Atomic Energy Research Institute, Daejeon, Korea ]
• Soonyoung Kim [ RADCORE, Co., Ltd., Daejeon, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629