Earticle

초록

영어

Background: The purpose of this study is to evaluate the immunosuppressive and antioxidant effects of a novel radioprotective agent using the vitamin E derivative 2-(alpha-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol (TMG) and its effect on tumors, and to study its usefulness. Materials and Methods: In this study, C57BL/6NCrSlc mice were divided into four groups (control, TMG, radiation therapy [RT], and RT+TMG), using 10 mice in each group. In the TMG and 2 Gy+TMG groups, 500 mg/kg TMG was administered. Two groups (2 Gy and 2 Gy+ TMG) among RT and RT+TMG groups were irradiated with 2 Gy in a single fraction, while the other two groups (6 Gy and 6 Gy+TMG) were irradiated locally with 6 Gy in three fractions. Results and Discussion: TMG positively affected CD4+ and CD8+ T lymphocytes. Tumor volumes and growth inhibition rates were compared. In order to evaluate how TMG administration affected tumor growth, Ehrlich cancer cells were injected into the thigh of mice, and the tumor volume and growth suppression rate were compared. Not only RT but also TMG alone inhibited tumor growth. If RT conducted to the mice with TMG, TMG could increase the number of leukocytes, primarily that of lymphocytes. TMG also inhibited tumor growth in addition to RT. Tumor growth was significantly inhibited in the 6 Gy+TMG group. Conclusion: In conclusion, TMG exerted an immunopotentiating effect mainly by increasing the white blood cell numbers including that of lymphocytes. In addition to RT, TMG also inhibited tumor growth. Therefore, TMG is considered to be a useful radioprotective agent in radiotherapy without tumor growth induction.

목차

ABSTRACT
Introduction
Materials and Methods
1. Animals and Maintenance
2. Radiation Delivery
3. Exp 1: Changes in White Blood Cell Numbers
4. Exp 2: Changes in T Lymphocytes
5. Exp 3: Effect on Tumor Growth
6. Exp 4: Effect on the TNF-α Level
7. TMG
Results and Discussion
1. Exp 1: Changes in white blood cell numbers
2. Exp 2: Changes in T Lymphocytes
3. Exp 3: Effect on Tumor Growth
4. Exp 4: Effect on the TNF-α Level
5. Discussion
Conclusion
Conflict of Interest
Ethical Statement
Author Contribution
References

키워드

저자

• Yeun-Hwa Gu [ Department of Radiological Science, Graduate School of Health Science, Junshin Gakuen University, Fukuoka, Japan ] Corresponding author
• Ryo Matsumoto [ Department of Radiological Science, Graduate School of Health Science, Junshin Gakuen University, Fukuoka, Japan ]
• Takenori Yamashita [ Department of Radiological Science, Faculty of Health Science, Suzuka University of Medical Science, Mie, Japan ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629