Earticle

초록

영어

Oxidative stress has been suggested to play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to investigate a link between malondialdehyde (MDA) levels, pulmonary function, and cardiac autonomic control in patients with COPD. Plasma levels of MDA, heart rate variability, and pulmonary function were mea-sured in 50 clinically stable COPD patients and 50 normal male controls. COPD patients exhibited lower means of the standard deviations of all normal to normal (NN) intervals (SDNN), the square root of the mean of the sum of the squares of differences between adjacent NN intervals (RMSSD), and high frequency (HF). Nevertheless, they presented great-er low frequency (LF) and low frequency/high frequency ratio (LF/HF ra-tio) in supine and head-up tilt positions than controls (P<0.001). More-over, a negative correlation between MDA levels with SDNN (P<0.001) and a positive correlation with LF (P<0.01) and LF/HF ratio (P<0.05) were observed in both positions. In COPD patients, plasma MDA levels were 2.3 times greater than controls (4.33±2.03 μM vs. 1.89±0.39 μM, P<0.001), and they were inversely correlated with forced vital capacity, forced expiratory volume in 1 sec, midexpiratory flow, and peak expira-tory flow (P<0.001). Our findings suggest a potential role for oxidative stress in impaired cardiac autonomic control and clinical relevance of plasma MDA levels as a predictor of severity of COPD in COPD patients.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Design and population
HRV measurement
Pulmonary function test
Oxidative stress marker
Statistical analysis
RESULTS
Demographic parameters of all participants
HRV parameters in supine and tilt positions
Plasma MDA in all participants
Correlation between plasma MDA and pulmonary function in COPD patients
Correlation between plasma MDA and HRV in COPD patients
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Tichanon Promsrisuk [ Division of Physiology, School of Medical Sciences, University of Phayao, Phayao, Thailand, Unit of Excellence in the Pulmonary and Cardiovascular Health Care, University of Phayao, Phayao, Thailand ]
• Orachorn Boonla [ Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand, Exercise and Nutrition Innovation and Sciences Research Unit, Burapha University, Chonburi, Thailand ] Corresponding author
• Ratchaniporn Kongsui [ Division of Physiology, School of Medical Sciences, University of Phayao, Phayao, Thailand ]
• Napatr Sriraksa [ Division of Physiology, School of Medical Sciences, University of Phayao, Phayao, Thailand, Unit of Excellence in the Pulmonary and Cardiovascular Health Care, University of Phayao, Phayao, Thailand ]
• Sitthisak Thongrong [ Division of Anatomy, School of Medical Sciences, University of Phayao, Phayao, Thailand ]
• Arunrat Srithawong [ Department of Physical Therapy, School of Allied Health Sciences, University of Phayao, Phayao, Thailand ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613