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Original Article

Current Prescription Status of Contraindicated Drug Combinations Causing Serotonin Syndrome: Analysis of HIRA-NPS Data

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제32권 제4호 (2022.12)바로가기
  • 페이지
    pp.313-320
  • 저자
    Jae Gon Ryu, So Young Kim, Susin Park, Nam Kyung Je4
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A422401

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원문정보

초록

영어
Background: Serotonin syndrome is a life-threatening disease if not appropriately treated. This study aimed to investigate the prescription status of contraindicated drug combinations that cause serotonin syndrome and identify the related factors. Methods: A cross-sectional study was conducted using nationwide claims data. Adult patients taking serotonergic drugs with Parkinson’s disease or mental disorders were selected. Based on international medical databases (MDBs) and the Korean Drug Utilization Review (DUR), the status of prescribing contraindicated drug combinations that induce serotonin syndrome, the related factors, and the difference between international MDBs and the Korean DUR were analyzed. Results: Of the 49,773 study subjects, 163 (0.3%) were prescribed contraindicated serotonergic drug combinations based on international MDBs, and among them, only 105 (64.4%) were contraindicated by the Korean DUR. Positive influencing factors for prescribing contraindicated drug combinations include patient age between 65 and 74 and physician’s specialties (neurologists, and orthopedists). Negative influencing factors were physician’s specialty (internists) and medical institution (primary institutions). Conclusion: Despite the implementation of DUR, 3 out of 1,000 study subjects received contraindicated drug combinations that caused serotonin syndrome. Hence, it is necessary to comply with the DUR and improve it in accordance with international MDBs.

목차

ABSTRACT
Methods
Data source
Patient population
Contraindicated drugs in combination
Statistical analysis
Results
Characteristics of study subjects
Prescribing status of contraindicated serotonergic drug combinations
Factors related to prescribing contraindicated drug combinations
Frequency of prescribing contraindicated drugs in combinations
Discussion
Conclusion
References

키워드

serotonin syndrome serotonin agents contraindications drug combinations drug utilization review

저자

  • Jae Gon Ryu [ Department of Pharmacy, Sungkyunkwan University Samsung Changwon Hospital, Changwon 51353, Republic of Korea ]
  • So Young Kim [ Department of Pharmacy, Kosin University Gospel Hospital, Busan 49267, Republic of Korea ]
  • Susin Park [ College of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea ] Corresponding Author
  • Nam Kyung Je4 [ College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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