Earticle

초록

영어

It has been known that chronic psychological or physical stress elicits depressive behaviors (learned helplessness, anhedonia, anxiety, etc.) and also activates to release proinflammatory cytokines in the brain. Especially, postmenopausal women under stress condition exacerbates neuroimmune systems and mood disorder. Repeated restraint stress in the ovariectomized female rats poses an immune challenge which was capable of inducing depressive-like behaviors, promoting exaggerated corticosterone responses and changing the proinflammatory cytokine expression such as interleukin (IL)-1β in the brain. Also, anti-inflammatory cytokines including IL-4 are known to regulate inflammation caused by immune response or stress challenge. Furthermore, some studies reported that physical activity can reduce stress hormones and improve personal immunity. Physical exercise has been shown to be associated with decreased symptoms of depression and anxiety, and with improved physical health, immunological function, and psychological well-being. This paper aims to discuss an overview of how stress shapes neuroimmune response and diverse roles of cytokines in animals models, acting on depressive-like behavioral changes; some beneficial aspects of exercise on stress-related disorders are addressed.

목차

Abstract
INTRODUCTION
THE ROLE OF ANTI-INFLAMMATORY CYTOKINES IN RESPONSE TO STRESS
THE DIFFERENTIAL EFFECTS OF CYTOKINES ON STRESS RESPONSES IN A MENOPAUSE ANIMAL MODEL
PREVENTIVE EFFECT OF ANTI-INFLAMMATORY CYTOKINES ON DEPRESSIVE-LIKE BEHAVIOR AND CENTRAL NEUROTRANSMITTER ALTERATIONS
THE ROLE OF PHYSICAL EXERCISE ON STRESS-RELATED DISEASES
CONCLUSION
REFERENCES

키워드

저자

• Hyun Jung Park [ Department of Food Science and Biotechnology, Kyonggi University, Suwon, Korea ]
• Sung Ja Rhie [ Department of Beauty Design, Halla University, Wonju, Korea ]
• Insop Shim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613