Earticle

초록

영어

A randomized control trial was conducted to investigate the synergistic effects of Gotu kola supplementation and multicomponent exercise on cognitive function, inflammation, and oxidative stress in older adults with mild cognitive impairment (MCI). Sixty participants aged 74.6±7.3 years with Mini-Mental State Examination (MMSE) scores of 20.7±2.6 were randomly assigned to one of three groups: a multicomponent exercise training group (EXE, n=20), a multicomponent exercise training with Gotu kola supplementation group (EXE+GK, n=20), or a placebo-controlled group (CON, n=20). Each participant received one capsule of placebo or 500 mg twice a day of Gotu kola extract. The multicomponent exer-cise program comprised of supervised resistance, aerobic, balance and dual-task training: three 80-min sessions/week for 12 weeks. The prima-ry outcomes, such as cognitive function, inflammatory markers, and ox-idative stress, were measured before and after the 12-week interven-tion. Following the interventions, the EXE and EXE+GK had significantly higher MMSE (P<0.01), Digit Span Forward test (DSF) (P<0.01), Digit Span Backward test (P<0.01) scores, and lower Trail Making Test parts A (P<0.01) and B (P<0.01) and lower 8-iso-prostaglandin F2α (P<0.01) and tumor necrosis factor alpha (TNF-α) (P<0.01) than the CON. The change in DSF and TNF-α in the EXE+GK had a negative correlation (r=-0.504, P<0.05). In conclusion, multicomponent exercise training with or without the supplement Gotu kola improves cognitive function, inflammation, and oxidative stress in older adults with MCI. Although supplementing with Gotu kola had no additional effects on cognitive function, it may improve the effects of multicomponent exercise on ex-ecutive function by decreasing TNF-α levels.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Participants
Study design
Preparation of crude extracts
Exercise intervention
Anthropometrics and body composition measurements
Blood samples collection
Biochemical analysis
Inflammatory markers and oxidative stress analysis
Cognitive function assessment
Functional mobility assessment
Statistical analysis
RESULTS
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Jatuporn Phoemsapthawee [ Department of Sports Science and Health, Faculty of Sports Science, Kasetsart University, Nakhon Pathom, Thailand ] Corresponding author
• Watthanaree Ammawat [ Division of Occupational Therapy, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand ]
• Piyapong Prasertsri [ Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand, Exercise and Nutrition Innovation and Sciences Research Unit, Burapha University, Chonburi, Thailand ]
• Pakaporn Sathalalai [ Central Laboratory and Greenhouse Complex, Research and Academic Service Center, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Nakhon Pathom, Thailand ]
• Naruemon Leelayuwat [ Graduate School, Khon Kaen University and Sports and Exercise Science Program and Research Group, Khon Kaen University, Khon Kaen, Thailand ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613