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Original Article

Norflurazon causes developmental defects including cardiovascular abnormalities in earlystage zebrafish (Danio rerio )

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  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Journal of Animal Reproduction and Biotechnology 바로가기
  • 통권
    Volume. 37 No. 3 (2022.09)바로가기
  • 페이지
    pp.176-182
  • 저자
    Garam An, Hahyun Park, Taeyeon Hong, Gwonhwa Song, Whasun Lim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A418679

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원문정보

초록

영어
Norflurazon is widely used on agricultural lands and has a high potential to pollute water sources. However, its effects on fish have not been fully elucidated. The purpose of our study was to determine whether norflurazon adversely affects the developmental stage of zebrafish, which are frequently used as a model system to evaluate the environmental impact of pollutants. Norflurazon interfered with the hatching of zebrafish embryos and induced several sublethal deformities including body length reduction, increased yolk sac volume, and enlargement of the pericardial region. We further examined the cardiotoxicity of norflurazon in the flk1:eGFP transgenic zebrafish line. The vascular network, mainly in the brain region, was significantly disrupted in norflurazon-exposed zebrafish. In addition, due to the failure of cardiac looping, norflurazon-exposed zebrafish had an abnormal cardiac structure. These developmental abnormalities were related to the apoptotic process triggered by norflurazon. Overall, the present study demonstrated the non-target toxicity of norflurazon by analyzing the hazardous effects of norflurazon on developing zebrafish.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Experimental organism
Herbicide exposure
Evaluation of toxicological endpoints
Visualization of the vasculature in norflurazon-treated zebrafish
Visualization of apoptotic cell death in norflurazon treatedzebrafish
Statistical analysis
RESULTS
Norflurazon causes sublethal alterations in developing zebrafish
The cardiovascular system of developing zebrafish isdisrupted by norflurazon exposure
Norflurazon triggers apoptotic cell death in developingzebrafish
DISCUSSION
CONCLUSION
REFERENCES

키워드

apoptosis cardiovascular toxicity developmental toxicity norflurazon zebrafish embryo

저자

  • Garam An [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ]
  • Hahyun Park [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ]
  • Taeyeon Hong [ Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea ]
  • Gwonhwa Song [ 1Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ] Corresponding Author
  • Whasun Lim [ Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Journal of Animal Reproduction and Biotechnology
  • 간기
    계간
  • pISSN
    2671-4639
  • eISSN
    2671-4663
  • 수록기간
    2019~2026
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Journal of Animal Reproduction and Biotechnology Volume. 37 No. 3

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