Earticle

초록

영어

Mecoprop-p, a chlorophenoxy herbicide, has been widely used since the 1980s. Due to its high water solubility, it could be detected in the aquatic environment, as it has already been detected in the surface water or groundwater in several countries. The toxicity of other chlorophenoxy herbicides has been reported; however, there are few studies on the toxicity of mecoprop-p, one of the chlorophenoxy herbicides, on aquatic organisms. Here, we investigated the toxic effects of mecoprop-p using zebrafish. After mecoprop-p exposure, we observed that the zebrafish larvae eyes did not form normally, heart edema was generated, and the body length was shortened. The number of cells undergoing apoptosis also increased in the anterior part including head, heart, and yolk sac of the mecoprop-p-treated zebrafish compared to the untreated controls. Moreover, cardiovascular structures, including the heart and aortic arches, were also malformed after exposure to mecoprop-p. Therefore, our results suggest that mecoprop-p could cause abnormal development in zebrafish larvae and there is also a high possibility that mecoprop-p would be toxic to other aquatic organisms.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Zebrafish breeding and embryo acquisition
Mecoprop-p treatment
Observation of morphological abnormalities in zebrafish larvae after mecoprop-p treatment
Determination of apoptotic cell number via acridine orange staining
Analysis of vascular damage in transgenic flk1:eGFP zebrafish larvae after mecoprop-p treatment
Statistical analysis
RESULTS
Mecoprop-p caused morphological abnormalities during early development in zebrafish larvae
Mecoprop-p increased the incidence of uncontrolled apoptosis in the anterior region of zebrafish larvae
Mecoprop-p exposure induced cardiovascular abnormalities
DISCUSSION
CONCLUSION
REFERENCES

키워드

저자

• Junho Park [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ]
• Garam An [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ]
• Hahyun Park [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ]
• Taeyeon Hong [ Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea ]
• Gwonhwa Song [ Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea ] Corresponding Author
• Whasun Lim [ Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea ] Corresponding Author

참고문헌

발행기관

간행물

관심저널 등록

• 간행물명

  Journal of Animal Reproduction and Biotechnology

• 간기

  계간

• pISSN

  2671-4639

• eISSN

  2671-4663

• 수록기간

  2019~2026

• 십진분류

  KDC 527 DDC 636