Earticle

초록

영어

In this study, the effect of chronic alcohol intake for 4 weeks on the muscular atrophy factors of rat skeletal muscle was studied using 6-week-old growing Sprague-Dawley rats. Experimental animals were classified into a control group and an alcohol intake group. The alcohol intake group consumed alcohol orally at a concentration of 3-g/kg body weight every day for 4 weeks. The control group consumed tap water in the same way. After 4 weeks alcohol ingestion, glucose, total choles-terol, triglyceride, and high-density lipoprotein cholesterol in serum lev-els were measured. Western blot was performed to detect the expres-sions of muscle RING-finger protein-1 (MuRF1), protein kinase B (Akt), phosphorylated Akt (p-Akt), forkhead box O (FoxO), phosphorylated FoxO (p-FoxO), p38, and phosphorylated p38 (p-p38). Results of this experiment showed that chronic alcohol intake enhanced triglyceride concentra-tion. Chronic alcohol intake increased MuRF1 expression to promote muscle proteolysis and decreased p-Akt/Akt ratio and p-FoxO/FoxO ra-tio to inhibit skeletal muscle growth. Therefore, alcohol consumption has been shown to cause muscle atrophy.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Blood sampling and serum component analysis
Muscle tissue pretreatment
Western blotting
Data analysis
RESULTS
Effect of alcohol intake on blood composition
Effect of alcohol intake on MuRF1 expression
Effect of alcohol intake on ratio of p-Akt/Akt expression
Effect of alcohol consumption on ratio of p-FoxO/FoxO expression
Effect of alcohol consumption on ratio of p-p38/p38 expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sung-Hwan No [ Department of Physical Education, College of Education, Inha University, Incheon, Korea ]
• Hwang-Woon Moon [ Department of Sports and Outdoors, College of Bio Convergence, Eulji University, Seongnam, Korea ]
• Jun-Su Kim [ Department of Sports and Outdoors, College of Bio Convergence, Eulji University, Seongnam, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613