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Anticancer effect of quercetin in human skin cancer cells through down-regulation of ganglioside GD3 expression

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2022 한국당과학회 연례학술대회 (2022.07)바로가기
  • 페이지
    pp.90-90
  • 저자
    Sang Young Seo, Won Seok Ju, Jin Ok Yu, Ji-Su Kim, Young-Kug Choo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A415495

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원문정보

초록

영어
Malignant melanoma is highly resistant to conventional treatments and is one of the most aggressive types of skin cancer. Conventional cancer treatments are limited due to drug resistance, tumor selectivity, and toxicities. Therefore, new treatments with fewer side effects and excellent effects should be developed. A ganglioside, a molecule composed of a glycosphingolipid, has crucial roles involved in cell-cell interaction, cell growth, proliferation, inflammation, differentiation, and tumorigenesis. Meanwhile, Quercetin (Qu) is considered that potentially inhibit cancer growth, proliferation, invasion, and metastasis, the relationship between its effects on malignant melanoma and ganglioside expression has not been clear. The aim of this study was to investigate the anti-cancer effects of Qu based on the relationship between protein structure and ganglioside on human skin cancer. In this study, quercetin, a flavonoid drug, did not induce toxicity in the human epithelial cell line HaCaT, but Its was abnormal cell elongation and morphological change in the proliferation and growth of skin cancer. Moreover, Its was treated so that cells in the G1/G0 phase cannot proceed to the subsequent S phase, which induces cell cycle arrest. The proliferation rate of cell migration was a certain range of proliferation was inhibited, it can be strongly assumed that this result is directly related to the expression of the various proteins analyzed above. Additionally, we discovered ganglioside decreased in melanoma with quercetin treatment. Taken together, it will be important evidence and present their potential as future therapeutic agents for treating carcinogenesis to figure out the molecular relationship between quercetin, ganglioside, and an anti-target protein of melanoma.

저자

  • Sang Young Seo [ Department of Biological Science, College of Natural sciences, Wonkwang University ]
  • Won Seok Ju [ Department of Biological Science, College of Natural sciences, Wonkwang University, 3Institute for Glycoscience, Wonkwang University, 460 Iksan-daero, Iksan-si, Jeonbuk 54538, Republic of Korea ]
  • Jin Ok Yu [ Department of Biological Science, College of Natural sciences, Wonkwang University ]
  • Ji-Su Kim [ Primate Resources Center (PRC), Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56216, Republic of Korea ]
  • Young-Kug Choo [ Department of Biological Science, College of Natural sciences, Wonkwang University, 3Institute for Glycoscience, Wonkwang University, 460 Iksan-daero, Iksan-si, Jeonbuk 54538, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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