Yeseul Park, Jin Young Kim, Jong Shin Yoo, Heeyoun Hwang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A415480
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원문정보
초록
영어
As a part of the Chromosome-centric Human Proteome Project (C-HPP), we have developed a few algorithms for accurate identification of missing proteins, alternative splicing variants, single amino acid variants, and characterization of function unannotated proteins. We have found missing proteins, novel and known ASVs, and SAAVs using LC-MS/MS data from human brain and olfactory epithelial tissue, where we validated their existence using synthetic peptides. We used the latest released neXtProt database (2022-02) which incorporates PeptideAtlas human (2022-01 build) and MassIVE, where they contains 2 and 7 new sample types (e.g. normal muscle, cancer from other female reproductive organ), respectively. According to the neXtProt database, the number of missing proteins in chromosome 11 shows a decreasing pattern. The development of genomic and transcriptomic sequencing techniques make the number of protein variants in chromosome 11 tremendously increase. For the 73 uPE1 in chromosome 11, we have studied the function annotaion of CCDC90B (NX_Q9GZT6), SMAP (NX_O00193), and C11orf52 (NX_Q96A22).
저자
Yeseul Park [ Research Center for Convergence Analysis, Korea Basic Science Institute, Cheongju 29118, Korea ]
Jin Young Kim [ Research Center for Convergence Analysis, Korea Basic Science Institute, Cheongju 29118, Korea ]
Jong Shin Yoo [ Research Center for Convergence Analysis, Korea Basic Science Institute, 2Graduate School of Analytical Science and Technology, Chungman National University ]
Heeyoun Hwang [ Research Center for Convergence Analysis, Korea Basic Science Institute, Cheongju 29118, Korea ]
Corresponding Author
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.