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Verification of the applicability of protein X based on aberrant glycosylation as a liver cancer biomarker

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2022 한국당과학회 연례학술대회 (2022.07)바로가기
  • 페이지
    pp.70-70
  • 저자
    Jihae Nam, Jung Soo Kim, Hee Won Kim, Jeong Gu Kang, Jeong-Heon Ko
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A415475

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원문정보

초록

영어
Early diagnosis and appropriate treatment can significantly lower the death rate from cancer, so the discovery of low-cost and high-efficiency cancer biomarkers for early diagnosis of cancer has been ongoing for a long time. However, most biomarkers based on quantitative differences are not limited to specific cancers and have inconsistent reproducibility, so they are used as an auxiliary form of diagnosis. Accordingly, we tried to discover biomarkers with improved diagnostic ability by considering not only quantitative differences but also qualitative differences, that is, changes in glycosylation. Protein X, which was confirmed to have a specific glycosylation structure in liver cancer patients through our previous study, was selected as a target protein, and its potential as a liver cancer biomarker was investigated through quantitative and qualitative analysis. In particular, to analyze the glycosylation pattern of protein X, an aglycosylated antibody-based lectin-coupled immunoassay was introduced and verified. As a result of analyzing the patient's clinical samples through this method, it was confirmed that the fucosylation pattern of protein X was similar to that of AFP, which the FDA approved as a biomarker. Therefore, the fucosylation of protein X is expected to have potential as a liver cancer biomarker.

키워드

Aglycosylated antibody Lectin coupled immunoassay Cancer biomarker Fucosylation

저자

  • Jihae Nam [ Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Biomolecular Science, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea ]
  • Jung Soo Kim [ Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 34141, Daejeon, Republic of Korea ]
  • Hee Won Kim [ Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Biomolecular Science, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea ]
  • Jeong Gu Kang [ Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Biomolecular Science, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea ] Corresponding Author
  • Jeong-Heon Ko [ Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Biomolecular Science, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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