Glycans, also known as carbohydrates, saccharides, or simply as sugars, play central roles in many biological processes and have useful properties in a variety of applications from biomarker discovery to therapeutics. However, glycans have received little attention from the research community due to the lack of tools to probe their often complex structures and properties. Recently, advances in glycomic and glycoproteomic methods along with the development of technology in mass spectrometry allow us to better understand the role of the glycome in biological processes in areas as broad as biotherapeutics, infection, brain, and cancer. The challenges are no longer scientific but technical. In this lecture, we will cover the glycomic methods that enables in-depth structural characterization of sugar chains and the glycoproteomic methods for obtaining comprehensive site-specific glycosylation information using mass spectrometry-based platforms. In addition, glyco-informatics and database that automate interpretation of glycome data, which are key to the broader implementation of glycoscience, will be discussed.
저자
Hyun Joo An [ Graduate School of Analytical Science & Technology, Chungnam National University, Asia-Pacific Glycomics Reference Site, Daejeon, South Korea ]
Corresponding Author
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.