Earticle

초록

영어

This study attempted to investigate the association between changes in the intestinal environment and the brain using a model that received aerobic exercise and microbiome transplantation. All mice were fed a diet containing 60% fat. For the obesity with nonexercise microbiome transplantation group, feces from donors that did not undergo exercise were administered. For the obesity with exercise microbiome trans-plantation group, feces from donors who underwent exercise were ad-ministered. Treadmill exercise started 16 weeks after the intake of the high fat feeding and continued for 24 weeks. The short-term memory and spatial learning memory were determined by step-down avoidance test and Morris water maze task, immunohistochemistry for glial fibril-lary acidic protein, western blot analysis for brain-derived neurotrophic factor and tropomyosin receptor kinase B were performed in the hippo-campus. Exercise was the most effective way to reduce obesity, im-prove memory function, suppress inflammation, and increase brain-de-rived neurotrophic factor expression. Intestinal microbiota transplanta-tion was the second most effective after exercise. However, there was no significant difference in the fecal microbiota transplant group ac-cording to whether or not exercise was performed.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
Treadmill exercise protocol
Fecal microbiota transplantation
Glucose tolerance test
Step-down avoidance test
Morris water maze task
Tissue preparation
Western blotting for brain-derived neurotrophic factor and tropomyosin receptor kinase B
Immunohistochemistry for glial fibrillary acidic protein
Collection of fecal samples, sequencing and metagenomic analysis
Data analysis
RESULTS
The effects of exercise and microbiome transplantation on body weight and blood glucose levels
The effects of exercise and microbiome transplantation on short-term memory and spatial learning memory
The effects of exercise and microbiome transplantation on BDNF and TrkB expression in the hippocampus
The effects of exercise and microbiome transplantation on GFAP-positive cells in the hippocampal dentate gyrus
The effects of exercise and microbiome transplantation in the gut microbiome
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Seong-Hyun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, College of Culture and Sports, Division of Global Sport Studies, Korea University, Sejong, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ College of Culture and Sports, Division of Global Sport Studies, Korea University, Sejong, Korea ]
• Yun-Jin Park [ Department of Health Rehabilitation, Osan University, Osan, Korea ]
• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613