Earticle

초록

영어

For humans, maternal old age means the age of 35 or older at the time of childbirth. Maternal metabolism not only affects the cognitive func-tion of the offspring, but also affects their physical and neurological de-velopment. This study aims to elucidate the effects of exercise training on spatial learning memory, neurogenesis, and apoptosis in the off-spring of old mice. Using mice, the offspring of old mothers showed im-paired spatial learning memory, decreased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, suppressed neuro-genesis, and increased hippocampal apoptotic cell death. In contrast, the offspring of the old mothers had improved spatial learning memory, increased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, increased neurogenesis, and decreased hippocampal apoptotic cell death when they received exercise training. The present results indicate that there is apparent spatial learning memory impair-ment among the offspring of old mothers, but by contrast, exercise can ameliorate spatial learning memory impairment. Exercise can be an ef-fective countermeasure against memory decline in the offspring of old mothers.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Exercise protocol
Preparation of tissue samples
Morris water maze
Immunofluorescence
Quantification of histology
Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining
Western blotting
Statistical analyses
RESULTS
Effect of exercise on spatial learning memory in offspring
Effect of exercise on hippocampal BDNF and PSD-95 levels in offspring
Effect of exercise on hippocampal Bax and Bcl-2 expressions in offspring
Effect of exercise on hippocampal neurogenesis in offspring
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ]
• Sang-Seo Park [ School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA, Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hye-Sang Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613