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Original Article

Morphological remodeling in mouse vagina due to hormonal hypersecretion

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Journal of Animal Reproduction and Biotechnology 바로가기
  • 통권
    Volume. 37 No. 1 (2022.03)바로가기
  • 페이지
    pp.42-47
  • 저자
    Min-Gee Oh, Sang-Hwan Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A410039

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원문정보

초록

영어
This study aimed to determine whether hormonal hypersecretion could cause morphological problems in the mouse vagina and affect the ovaries and nearby extra uterine organs. All mice were synchronized to estrus before the experiment. Then human chorionic gonadotropin (hCG), progesterone, and testosterone were continuously administered for about 6 days to maintain hormone hypersecretion, and then morphological changes were analyzed, and Matrix metalloproteinases (MMPs) activity and Casp-3 expression were evaluated. As a result of the analysis, in the case of hCG, the morphological change did not show a significant difference from the vagina of normal estrus. In the case of progesterone, changes were observed in the mucosa zone and basal membrane, and it was confirmed that the activity of MMPs was increased in squamous epithelium cells. On the other hand, in the case of testosterone, overall changes in vaginal tissues were observed, and MMPs activity was increased to a very high level in all sections. The expression of Casp-3 was also the highest compared to other groups. Therefore, as a result of this study, it is thought that hormone hypersecretion affects the morphological changes of the vagina other than the ovaries and uterus and induces the activity of MMPs to cause morphological degeneration of tissues.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Preparation and certification of animals
Histological of the vagina tissue
In-situ Zymography
Immuno-detected of vagina tissue protein
Statistical analysis
RESULTS
Morphological changes in vaginal tissue due to hormonal hypersecretion
Analysis of cell distribution in vaginal lining tissue
Analysis of MMP activity and Casp-3 expression pattern in the vaginal tissue
DISCUSSION
CONCLUSION
REFERENCES

저자

  • Min-Gee Oh [ General Graduate School of Animal Life Convergence Science, Hankyong National University, Ansung 17579, Korea ]
  • Sang-Hwan Kim [ School of Animal Life Convergence Science, Hankyong National University, Ansung 17579, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Journal of Animal Reproduction and Biotechnology
  • 간기
    계간
  • pISSN
    2671-4639
  • eISSN
    2671-4663
  • 수록기간
    2019~2026
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Journal of Animal Reproduction and Biotechnology Volume. 37 No. 1

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