Earticle

초록

영어

Functional dyspepsia (FD) is a gastrointestinal disorder with diverse symptoms but no structural or organic manifestations. Benachio-F® (herein named ‘BF-1’) is an over-the-counter liquid digestive formulated with multiple herbal extracts, which has been reported to improve symptoms of FD. A total two experiments were conducted. First, we examined whether BF-1 can modulate the progression of FD through two experimental rat models. A total of three doses (0.3x, 1x, 3x of the human equivalent dose) were used. In the gastric emptying model, both 1x (standard) or 3x (3-fold-concentrated) BF-1 enhanced gastric emptying was compared with that of vehicle-treated animals. In a feeding inhibition model induced by acute restraint stress, treatment with 1x or 3x BF-1 led to a similar degree of restoration in food intake that was comparable to that of acotiamide-treated animals. Among the constituents of BF, fennel is known for its choleretic effect. Thus, we next investigated whether a novel BF-based formula (named ‘BF-2’) that contains an increased amount of fennel extract (3.5-fold over BF-1), has greater potency in increasing bile flow. BF-2 showed a superior choleretic effect compared to BF-1. Furthermore, the postprandial concentration of serum secretin was higher in animals pretreated with BF-2 than in those pretreated with BF-1, suggesting that the increased choleretic effect of BF-2 is related to secretin production. Our results demonstrate that BF-1 can modulate the pathophysiological mechanisms of FD by exerting prokinetic and stress-relieving effects, and that BF-2 has a better choleretic effect than BF-1.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Reagents
Animal experiments
RESULTS
The effect of BF-1 on gastric emptying
The effect of BF-1 on restoring restraint-induced acute stress
The effect of BF-2 on bile flow
The effect of BF-2 on the concentration of serum secretin
DISCUSSION
CONCLUSION
REFERENCES

키워드

저자

• Hye Jin Cho [ Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea ]
• Jun Su Im [ Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea ]
• Yong Sam Kwon [ Research Center, Dong-A Pharmaceutical Co., Ltd., Yongin 17073, Korea ]
• Kyung Soo Kang [ Department of Bio Life Science, Life & Environment Field, Shingu College, Seongnam 13174, Korea ]
• Tae Min Kim [ Graduate School of International Agricultural Technology, Seoul National University, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea ] Corresponding Author

참고문헌

발행기관

간행물

관심저널 등록

• 간행물명

  Journal of Animal Reproduction and Biotechnology

• 간기

  계간

• pISSN

  2671-4639

• eISSN

  2671-4663

• 수록기간

  2019~2025

• 십진분류

  KDC 527 DDC 636