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4부 초청강연 Session II Glycobiology of diseases and infections

Genetic diversity and genotype-dependent pathogenicity of dabie bandavirus (SFTSV) in South Korea

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2021 한국당과학회 연례학술대회 (2021.07)바로가기
  • 페이지
    pp.33-34
  • 저자
    Su-Jin Park, Young-Il Kim, Seok-Min Yun, Eun-Ha Kim, Hye Won Jeong, Young Ki Choi
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A406568

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원문정보

초록

영어
Background. Dabie Bandavirus (SFTSV) is an emerging tick-bone infectious disease in eastern Asia. This virus causes thrombocytopenia syndrome with 12-30% fatality. However, the genetic diversity of SFTSVs and the associations between specific genotypes and clinical outcomes are poorly understood. Methods. We isolated SFTSVs from SFTS-suspected patients in 207 hospitals throughout South Korea between 2013 and April of 2017 to investigate the nationwide SFTSV infection status. Using the ferret animal model, we demonstrated the genotype- and age-dependent pathogenicities of SFTSVs. Results. A total of 116 SFTSVs were isolated from 3,137 SFTS-suspected patients with an overall 21.6% case fatality rate. Genetic characterization revealed that at least 15 genotypes of SFTSVs are co-circulating in South Korea with multiple reassortments among them. The genotype B strains were the most prevalent (69.4%, 93/134) followed by the A and F genotypes. Clinical and epidemiologic investigations revealed that genotype B strains were associated with the highest case-fatality rate (34.8%, 32/92), while genotype A caused only one case fatality out of ten patients. Further, ferret infection studies demonstrated age-dependent close associations among clinical manifestations, mortality rates, and genotypes of SFTSV. Conclusions. Due to active reassortment events, diverse genotypes of SFTSV are co-circulating in South Korea, with genotype B strains being most dominant. Clinical and experimental investigations revealed that the genotype B strains showed the highest case-fatality rate. These results suggest that the variation in SFTS mortality rates in different regions might be due to the prevalence of different SFTSV strains and age of patients.

키워드

SFTSV clinical manifestations genotypes pathogenesis

저자

  • Su-Jin Park [ Division of Life Science, Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ]
  • Young-Il Kim [ College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ]
  • Seok-Min Yun [ College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ]
  • Eun-Ha Kim [ College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ]
  • Hye Won Jeong [ College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ]
  • Young Ki Choi [ College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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