This study was conducted to understand alcohol kinetics for Koreans and to present reasonable parameters for the application of the Widmark equation. A total of 44 healthy adults(11 female and 33 male) was selected and assigned to drink 1 g of ethanol per kg body weight of individual within 1 hour. Blood samples were then collected every 15 min for the first 3 h, 30 min next 3 h, and 1 h last 9 h. All samples were analyzed by gas chromatography with a flame ionization detector(GC-FID) for blood alcohol concentration(BAC). The maximum BAC(Cmax) was 0.145 ± 0.028%(g/100 mL) in average under the controlled experimental condition. Alcohol elimination rates(β-slope) in average were 0.0185 ± 0.0025 %/h for male and 0.0211 ± 0.0025 %/h for female, respectively. Widmark’s factor(rho-factor, r) in average were 0.61 ± 0.060 L/kg for male and 0.56 ± 0.073 L/kg for female. The Widmark alcohol calculation for Koreans is suggested that 1) It cannot be argued about the absorption rate due to the diversity of drinking types 2) The rapid absorption phase is an average of 15 minutes after drinking and there is no significant change in the first 1 hour 3) If the BAC is less than 0.02% or within 90 minutes of the end of drinking, the back-calculation is not possible 4) Estimation of alcohol concentration should be calculated as decreasing from the start time of drinking 5) The elimination rate is 0.0192 ± 0.0027 %/h for drinking driver 6) Widmark's factor should be calculated individually based on height, weight, sex and age.
목차
Abstract Ⅰ. 서론 Ⅱ. 임상시험 및 분석 1. 대상자 선정 및 임상시험 과정 2. 재료 및 표준시약 3. 실험방법 및 분석 Ⅲ. 결과 및 고찰 1. 임상시험 결과 2. 위드마크 식 적용 제안 Ⅳ. 결론 Ⅴ. 사사 Ⅵ. 참고문헌
법과학 분야는 사회정의 구현에 있어 크나큰 가치가 있음에도 불구하고 우리나라에서는 이 분야에 대한 인식이 미흡하여 선진 외국에 비해 침체되어 있는 실정이다. 이에 우리나라에서도 법과학 분야와 관련 있는 학계, 연구기관, 수사기관 등 유관 단체들로 구성된 한국 법과학회를 창립하여 이 분야를 활성화 시켜 과학수사를 한층 더 발전시키기 위함을 목적으로 한다.