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초록

Therapeutic and redox effect of hydrogen mineral disinfectant on Helicobacter pylori-infected C57BL/6 mouse model

첫 페이지 보기
  • 발행기관
    한국물학회 바로가기
  • 간행물
    한국물학회지 바로가기
  • 통권
    Vol.9 No.1 (2021.11)바로가기
  • 페이지
    pp.36-36
  • 저자
    Md. Habibur Rahman, Johny Bajgai, Yoojin Cho, Cheol-Su Kim, Kyu-Jae Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A403237

원문정보

초록

영어
Disinfectant which possesses hypochlorous acid (HOCl) as a predominant species has been widely used due to its strong sterilizing power, easy accessibility, low toxicity and various biological effects. The hydrogen mineral disinfectant (HMD) was developed through mixing method in a specific ratio based on hypochlorite and mineral supplements, which reveals high oxidizing power and abundant hydrogen. In this study we investigated drinking effects of HMD on Helicobacter pylori infection in C57BL/6 mice for 10 wk. The mice were divided into 3 groups: purified water (PW)-drinking group without infection, PW-drinking group after H. pylori infection and HMD-drinking group after H. pylori infection. Water was supplied with bottle for mouse and exchanged once a day. H. pylori infection was confirmed by microscopic observation through Giemsa staining. In the result, ROS level, GPx activity and calcium showed significant difference between HMD and PW group. the WBC differential counting, and cytokine analysis such as granulocyte/macrophage colony-stimulating factor, tumor necrosis factor-α, IL-1β, IL-6 also showed suppressive effect. In conclusion, our results suggest that drinking HMD which is the mixed type of chlorine disinfectant has positive effects on the H. pylori-infected mice through redox regulation and immune response.

키워드

hydrogen mineral disinfectant drinking effect helicobacter pylori redox regulation immune response

저자

  • Md. Habibur Rahman [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Department of Global Medical Science, Yonsei University Graduate School, Wonju, Gangwon-do, 26426 Republic of Korea ]
  • Johny Bajgai [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, 26426 Republic of Korea ]
  • Yoojin Cho [ Department of Chemical Biology, University of California, Berkeley, 94720 United States of America ]
  • Cheol-Su Kim [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, 26426 Republic of Korea ]
  • Kyu-Jae Lee [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, 26426 Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국물학회 [The Korean Water Society]
  • 설립연도
    2010
  • 분야
    자연과학>생물학
  • 소개
    기능수관련연구 경영과 정보를 공유, 일본 중국기능수재단 협회전문가 초빙하여 학회와의 정보교류 기능수관련 학회 및 학술지를 발행하여 물관련연구정보교류에 목적을 두고 있음.

간행물

  • 간행물명
    한국물학회지 [Korean Journal of Waters]
  • 간기
    부정기
  • pISSN
    2233-4653
  • 수록기간
    2010~2021
  • 십진분류
    KDC 539 DDC 628

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