Earticle

초록

영어

Chronic cerebral hypoperfusion (CCH) is caused by reduced blood flow to the brain representing gradually cognitive impairment. CCH induces mitochondrial dysfunction and neuronal cell death in the brain. Exercise is known to have a neuroprotective effect on brain damage and cognitive dysfunction. This study aimed to clarify the neuroprotective effect of low-intensity treadmill exercise (LITE) by enhancing cerebellar mitochondrial calcium retention capacity in an animal model of CCH. Wistar rats were divided into the sham group, the bilateral common carotid arteries occlusion (BCCAO) group, and the BCCAO and treadmill exercise (BCCAO+Ex) group. BCCAO+Ex group engaged the LITE on a treadmill for 30 min once a day for 8 weeks before the BCCAO surgery to investigate the protective effect of LITE on cognitive impairment. CCH induced by BCCAO resulted in mitochondrial dysfunction in the cerebellum, including impaired calcium homeostasis. CCH also decreased cerebellar Purkinje cells including of calbindin D28k and parvalbumin, resulting in cognitive impairment. The impairment of mitochondrial function, loss of cerebellar Purkinje cells, and cognitive dysfunction ameliorated by exercise. The present study showed that LITE hindered the deficit of spatial working memory and loss of Purkinje cell in the cerebellum induced by CCH. We confirmed that the protective effect of LITE on Purkinje cell by enhanced the mitochondrial calcium retention capacity. We suggest that LITE may protect against cognitive impairment, and further studies are needed to develop the intervention for patients who suffered from CCH.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Bilateral common carotid arteries occlusion
LITE protocol
Radial arm maze test
Immunohistochemistry
Mitochondrial calcium retention capacity
Statistical analysis
RESULTS
Protected cognitive performance
Decreased loss of Purkinje cell
Enhanced mitochondrial calcium retention capacity
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Jae-Min Lee [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ] co-first authors.
• Jongmin Park [ Research Institute of Nursing Science, College of Nursing, Pusan National University, Yangsan, Korea ] co-first authors.
• Joo-Hee Lee [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Hyo-Bum Kwak [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Mi-Hyun No [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Jun-Won Heo [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Youn-Jung Kim [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613