Earticle

초록

영어

Memory state of rat pups born to old and obese mother rats and the ef-fect of a treadmill running of mother rats on the memory of rat pups were studied. The radial 8-arm maze test was performed to detect spa-tial learning memory, and the level of tumor necrosis factor-α, interleu-kin (IL)-1β, and IL-6 in the hippocampus was measured by enzyme- linked immunoassay. Western blotting was performed for the expres-sion of nuclear factor kappa-light-chain-enhancer (NF-κB), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, al-pha (IκB-α), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), matrix metalloproteinase (MMP)-9, and immunohistochemistry for caspase-3 was conducted. The newborn rats were classified into fol-lowing groups: pups born to old mother rats, pups born to old mother rats with exercise, pups born to old and obese mother rats, and pups born to old and obese mother rats with exercise. Exercise of mother ameliorated spatial learning memory impairment, inhibited proinflam-matory cytokines production, NF-κB expression, and IκB-α phosphory-lation of the pups born to old and obese mother rats. Maternal exercise suppressed Bax expression, the number of caspase-3, the level of MMP-9, and enhanced Bcl-2 expression of the pups born to old and obese mother rats. When the maternal exercise was performed, the impairment of spatial learning memory in pups was ameliorated. There-fore, it can be seen that exercise during pregnancy of older and obese mothers is an important factor in fetal health management.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Animals and classification
Radial 8-arm maze test
Enzyme-linked immunoassay
Western blot
Immunohistochemistry
RESULTS
Spatial learning memory
Proinflammatory cytokines
NF-κB expression and p-IκB-α to IκB-α ratio
Bax and Bcl-2 expression
Caspase-3 immunohistochemistry
MMP-9 expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sang-Hoon Kim [ Department of Sport & Health Sciences, College of Art & Culture, Sangmyung University, Seoul, Korea, Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Kore ]
• Il-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jun-Jang Jin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Lakkyong Hwang [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Sciences, College of Art & Culture, Sangmyung University, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613