Earticle

초록

영어

Obesity causes atrophy of the brain, leading to deterioration in working memory, learning, and cognitive function. The status of short-term memory in rat pups born to older obese mother rats was verified, and the effect of treadmill exercise on short-term memory in rat pups was investigated. Step-down avoidance test for short-term memory, termi-nal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining for apoptosis, and immunohistochemistry for Ki67 for new cell generation were done. The old female rats were fed with nor-mal diet (5% of fat), and the old and obese female rats were fed with high-fat diet (60% of fat) for up to 50 weeks in age (for 44 weeks in ex-perimental period). The newborn rats were divided into four groups ac-cording to the conditions of the mother rats as follows: the rat pups group born to old rats, the rat pups group born to old rats with exercise, the rat pups group born to old and obese rats, the rat pups group born to old and obese rats with exercise. Maternal exercise improved short-term memory, decreased TUNEL-positive cell number, and increased Ki67-positive cell number of the pups born to old and obese rats. Mater-nal exercise has been found to contribute to eliminating the health risks of fetuses born to old obese mothers.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and classification
Step-down avoidance test
TUNEL staining
Ki67 immunohistochemistry
RESULTS
Short-term memory
Apoptosis
New cell generation
DSCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES
CONFLICT OF INTEREST

키워드

저자

• Young Jun Ko [ Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613